[HTML][HTML] Model-informed precision dosing: State of the art and future perspectives
Abstract Model-informed precision dosing (MIPD) stands as a significant development in
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …
Long-term immunosuppression management: opportunities and uncertainties
D Wojciechowski, A Wiseman - … Journal of the American Society of …, 2021 - journals.lww.com
The long-term management of maintenance immunosuppression in kidney transplant
recipients remains complex. The vast majority of patients are treated with the calcineurin …
recipients remains complex. The vast majority of patients are treated with the calcineurin …
Sirolimus and secondary skin-cancer prevention in kidney transplantation
S Euvrard, E Morelon, L Rostaing… - … England Journal of …, 2012 - Mass Medical Soc
Background Transplant recipients in whom cutaneous squamous-cell carcinomas develop
are at high risk for multiple subsequent skin cancers. Whether sirolimus is useful in the …
are at high risk for multiple subsequent skin cancers. Whether sirolimus is useful in the …
Renal association clinical practice guideline in post-operative care in the kidney transplant recipient
These guidelines cover the care of patients from the period following kidney transplantation
until the transplant is no longer working or the patient dies. During the early phase …
until the transplant is no longer working or the patient dies. During the early phase …
Consensus recommendations for use of maintenance immunosuppression in solid organ transplantation: Endorsed by the American College of Clinical Pharmacy …
J Nelson, N Alvey, L Bowman, J Schulte… - … : The Journal of …, 2022 - Wiley Online Library
Advances in maintenance immunosuppression over the past three decades have improved
solid organ transplantation outcomes dramatically. Uninterrupted access to …
solid organ transplantation outcomes dramatically. Uninterrupted access to …
Sirolimus and mTOR inhibitors: a review of side effects and specific management in solid organ transplantation
LS Nguyen, M Vautier, Y Allenbach, N Zahr… - Drug safety, 2019 - Springer
Inhibitors of mechanistic target of rapamycin (mTOR inhibitors) are used as antiproliferative
immunosuppressive drugs and have many clinical applications in various drug …
immunosuppressive drugs and have many clinical applications in various drug …
The translational machinery of human CD4+ T cells is poised for activation and controls the switch from quiescence to metabolic remodeling
Naive T cells respond to T cell receptor (TCR) activation by leaving quiescence, remodeling
metabolism, initiating expansion, and differentiating toward effector T cells. The molecular …
metabolism, initiating expansion, and differentiating toward effector T cells. The molecular …
Roles of mTOR complexes in the kidney: implications for renal disease and transplantation
The mTOR pathway has a central role in the regulation of cell metabolism, growth and
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …
[HTML][HTML] ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious …
Background The present review is part of the European Society of Clinical Microbiology and
Infectious Diseases (ESCMID) Study Group for Infections in Compromised Hosts (ESGICH) …
Infectious Diseases (ESCMID) Study Group for Infections in Compromised Hosts (ESGICH) …
Predicting clinical events by combining static and dynamic information using recurrent neural networks
In clinical data sets we often find static information (eg patient gender, blood type, etc.)
combined with sequences of data that are recorded during multiple hospital visits (eg …
combined with sequences of data that are recorded during multiple hospital visits (eg …