The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …

The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one
of the most significant environmental DNA-damaging agents to which humans are exposed …

Transcription-coupled DNA repair removes bulky DNA lesions from the genome, and
protects cells against ultraviolet (UV) irradiation. Transcription-coupled DNA repair begins …

DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple
forms, and if allowed to persist, can promote genome instability and directly lead to various …

The response to DNA damage-stalled RNA polymerase II (RNAPIIo) involves the assembly
of the transcription-coupled repair (TCR) complex on actively transcribed strands. The …

Expressed genes are scanned by translocating RNA polymerases, which sensitively detect
DNA damage and initiate transcription-coupled repair (TCR), a subpathway of nucleotide …

From its very beginning, life has faced the fundamental problem that the form in which
genetic information is stored is not chemically inert. DNA integrity is challenged by the …

Eukaryotic transcription-coupled repair (TCR) is an important and well-conserved sub-
pathway of nucleotide excision repair that preferentially removes DNA lesions from the …

Over the past few years, media have popularized the story of the “children of the moon” who
must remain in the dark and avoid exposure to sunlight. 1r3 These children suffer from a rare …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …