Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …

Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-
phosphate (S1P), are produced by the metabolism and perturbation of biological …

Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …

Natural products are mainly secondary metabolites produced by plants, microorganisms,
and animals, which are still abundant in modern drug discovery. Terpenoids are the most …

Neutrophils, the most abundant white blood cells in humans, are critical for host defense
against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils …

Neutrophil granulocytes form the first line of host defense against invading pathogens and
tissue injury. They are rapidly recruited from the blood to the affected sites, where they …

Timely resolution of the acute inflammatory response (or inflammation resolution) is an
active, highly coordinated process that is essential to optimal health. Inflammation resolution …

Inflammation and its timely resolution are critical to ensure effective host defense and
appropriate tissue repair after injury and or infection. Chronic, unresolved inflammation …