There are 2 populations of T lymphocytes, αβ T and γδ T cells, that can be distinguished by
the expression of either an αβ TCR or a γδ TCR, respectively. Pairing of the Ag binding …

D native electrophoresis is used for the separation of individual proteins, protein complexes,
and supercomplexes. Stable and labile protein–protein interactions can be identified …

Parkinsonism typified by sporadic Parkinson disease is a prevalent neurodegenerative
disease. Mutations in PINK1 (PTEN-induced putative kinase 1), a mitochondrial Ser/Thr …

The T-cell antigen receptor (TCR) exists in monomeric and nanoclustered forms
independently of antigen binding. Although the clustering is involved in the regulation of T …

Although memory T cells respond more vigorously to stimulation and they are more sensitive
to low doses of antigen than naive T cells, the molecular basis of this increased sensitivity …

Multiprotein complexes (MPCs) play a crucial role in cell signalling, since most proteins can
be found in functional or regulatory complexes with other proteins (Sali, Glaeser et al. 2003) …

Despite the low affinity of the T‐cell antigen receptor (TCR) for its peptide/major
histocompatibility complex (pMHC) ligand, T cells are very sensitive to their antigens. This …

Antigen binding to the B-cell antigen receptor (BCR) leads to receptor triggering and B-
lymphocyte activation. Here, we have probed the molecular requirements for BCR triggering …

In the last decade an increasing number of plasma membrane (PM) proteins have been
shown to be non-randomly distributed but instead forming submicron-sized oligomers called …

The γδ T cell receptor for antigen (TCR) comprises the clonotypic TCRγδ, the CD3 (CD3γε
and/or CD3δε), and the ζζ dimers. γδ T cells do not develop in CD3γ-deficient mice, whereas …