Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein
J Lei, Y Kusov, R Hilgenfeld - Antiviral research, 2018 - Elsevier
The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the
coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an …
coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an …
From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses
R Hilgenfeld, M Peiris - Antiviral research, 2013 - Elsevier
This article introduces a series of invited papers in Antiviral Research marking the 10th
anniversary of the outbreak of severe acute respiratory syndrome (SARS), caused by a …
anniversary of the outbreak of severe acute respiratory syndrome (SARS), caused by a …
Boron containing compounds as protease inhibitors
Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes
Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory
Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units …
Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units …
Molecular basis for ADP-ribose binding to the Mac1 domain of SARS-CoV-2 nsp3
The virus that causes COVID-19, SARS-CoV-2, has a large RNA genome that encodes
numerous proteins that might be targets for antiviral drugs. Some of these proteins, such as …
numerous proteins that might be targets for antiviral drugs. Some of these proteins, such as …
Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles
BW Neuman - Antiviral research, 2016 - Elsevier
Replication of eukaryotic positive-stranded RNA viruses is usually linked to the presence of
membrane-associated replicative organelles. The purpose of this review is to discuss the …
membrane-associated replicative organelles. The purpose of this review is to discuss the …
Macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV) is an efficient ADP-ribose binding module: crystal structure and biochemical studies
The newly emerging Middle East respiratory syndrome coronavirus (MERS-CoV) encodes
the conserved macro domain within non-structural protein 3. However, the precise …
the conserved macro domain within non-structural protein 3. However, the precise …
Atlas of coronavirus replicase structure
The international response to SARS-CoV has produced an outstanding number of protein
structures in a very short time. This review summarizes the findings of functional and …
structures in a very short time. This review summarizes the findings of functional and …
X-ray structural and functional studies of the three tandemly linked domains of non-structural protein 3 (nsp3) from murine hepatitis virus reveal conserved functions
Murine hepatitis virus (MHV) has long served as a model system for the study of
coronaviruses. Non-structural protein 3 (nsp3) is the largest nsp in the coronavirus genome …
coronaviruses. Non-structural protein 3 (nsp3) is the largest nsp in the coronavirus genome …
Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data
Serum albumin is one of the most widely studied proteins. It is the most abundant protein in
plasma with a typical concentration of 5 g/100 mL and the principal transporter of fatty acids …
plasma with a typical concentration of 5 g/100 mL and the principal transporter of fatty acids …