Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …

Resolution of inflammation: what controls its onset?

MA Sugimoto, LP Sousa, V Pinho, M Perretti… - Frontiers in …, 2016 - frontiersin.org
An effective resolution program may be able to prevent the progression from non-resolving
acute inflammation to persistent chronic inflammation. It has now become evident that …

Allergic rhinitis: mechanisms and treatment

DI Bernstein, G Schwartz… - … and Allergy Clinics, 2016 - immunology.theclinics.com
Atopic diseases, including allergic rhinitis (AR), are very prevalent, especially in developed
countries. Prevalence estimates of chronic rhinitis around the world range between 10% and …

Histamine: a mediator of intestinal disorders—a review

S Smolinska, E Winiarska, A Globinska, M Jutel - Metabolites, 2022 - mdpi.com
Within the gastrointestinal tract, histamine is present at relatively high concentrations,
especially during inflammatory processes. Histamine is a biogenic amine with numerous …

[HTML][HTML] Yin-yang of IL-33 in human skin mast cells: Reduced degranulation, but augmented histamine synthesis through p38 activation

M Babina, Z Wang, K Franke, S Guhl, M Artuc… - Journal of Investigative …, 2019 - Elsevier
Mast cells (MCs) are the principal effector cells of IgE-mediated allergy. IL-33 is released by
resident skin cells as alarmin upon tissue damage or allergen contact. Owing to their …

Functional anatomy and physiology of gastric secretion

ML Schubert - Current opinion in gastroenterology, 2015 - journals.lww.com
Functional anatomy and physiology of gastric secretion : Current Opinion in Gastroenterology
Functional anatomy and physiology of gastric secretion : Current Opinion in Gastroenterology …

Review of potential medical treatments for middle ear cholesteatoma

M Schürmann, P Goon, H Sudhoff - Cell Communication and Signaling, 2022 - Springer
Middle ear cholesteatoma (MEC), is a destructive, and locally invasive lesion in the middle
ear driven by inflammation with an annual incidence of 10 per 100,000. Surgical …

Enigmatic Histamine Receptor H4 for Potential Treatment of Multiple Inflammatory, Autoimmune, and Related Diseases

P Mehta, P Miszta, P Rzodkiewicz, O Michalak… - Life, 2020 - mdpi.com
The histamine H4 receptor, belonging to the family of G-protein coupled receptors, is an
increasingly attractive drug target. It plays an indispensable role in many cellular pathways …

Mechanisms of unconventional CD8 Tc2 lymphocyte induction in allergic contact dermatitis: Role of H3/H4 histamine receptors

J Alcain, AP Infante Cruz, G Barrientos… - Frontiers in …, 2022 - frontiersin.org
Histamine (HA) is a potent mediator that plays a central role in inflammation and allergy,
acting through four G-protein-coupled receptors (ie H1–H4). HA is an accepted promoter of …

[HTML][HTML] MHTP, a synthetic alkaloid, attenuates combined allergic rhinitis and asthma syndrome through downregulation of the p38/ERK1/2 MAPK signaling pathway …

LKDP Ferreira, LAMP Ferreira, GCB Barros… - International …, 2021 - Elsevier
The combined allergic rhinitis and asthma syndrome (CARAS) is a chronic airway
inflammation of allergic individuals, with a type 2 immune response. Pharmacotherapy is …