Autophagy is essential for neuronal homeostasis, and its dysfunction has been directly
linked to a growing number of neurodegenerative disorders. The reasons behind …

Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders
caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with …

Protein aggregation is a continuous process in our cells. Some proteins aggregate in a
regulated manner required for different vital functional processes in the cells whereas other …

Repeat expansion mutations cause at least 22 inherited neurological diseases. The
complexity of repeat disease genetics and pathobiology has revealed unexpected shared …

Stressors ranging from nutrient deprivation to immune signaling can induce the degradation
of cytoplasmic material by a process known as autophagy. Increasingly, research on …

One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

Intensive scientific research devoted in the recent years to understand the molecular
mechanisms or neurodegeneration in spinocerebellar ataxias (SCAs) are identifying new …

Proteolytic cleavage of huntingtin (Htt) is known to be a key event in the pathogenesis of
Huntington's disease (HD). Our understanding of proteolytic processing of Htt has thus far …

Under stress conditions, pro-survival and pro-death processes are concomitantly activated
and the final outcome depends on the complex crosstalk between these pathways. In most …

The autophagy-lysosomal pathway is a major proteolytic pathway that in mammalian
systems mainly comprises of macroautophagy and chaperone-mediated autophagy. The …