Illuminating dendritic function with computational models

P Poirazi, A Papoutsi - Nature reviews neuroscience, 2020 - nature.com
Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

The brain in motion: How ensemble fluidity drives memory-updating and flexibility

W Mau, ME Hasselmo, DJ Cai - Elife, 2020 - elifesciences.org
While memories are often thought of as flashbacks to a previous experience, they do not
simply conserve veridical representations of the past but must continually integrate new …

A stable hippocampal code in freely flying bats

WA Liberti III, TA Schmid, A Forli, M Snyder… - Nature, 2022 - nature.com
Neural activity in the hippocampus is known to reflect how animals move through an
environment,. Although navigational behaviour may show considerable stability,,–, the …

Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis

AD Umpierre, B Li, K Ayasoufi, WL Simon, S Zhao… - Neuron, 2024 - cell.com
Microglial calcium signaling is rare in a baseline state but strongly engaged during early
epilepsy development. The mechanism (s) governing microglial calcium signaling are not …

Miniscope-LFOV: a large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals

C Guo, GJ Blair, M Sehgal, FN Sangiuliano Jimka… - Science …, 2023 - science.org
Imaging large-population, single-cell fluorescent dynamics in freely behaving animals larger
than mice remains a key endeavor of neuroscience. We present a large-field-of-view open …

NINscope, a versatile miniscope for multi-region circuit investigations

A de Groot, BJG van den Boom, RM van Genderen… - Elife, 2020 - elifesciences.org
Miniaturized fluorescence microscopes (miniscopes) have been instrumental to monitor
neural signals during unrestrained behavior and their open-source versions have made …

Volatile working memory representations crystallize with practice

A Bellafard, G Namvar, JC Kao, A Vaziri, P Golshani - Nature, 2024 - nature.com
Working memory, the process through which information is transiently maintained and
manipulated over a brief period, is essential for most cognitive functions,,–. However, the …

BehaviorDEPOT is a simple, flexible tool for automated behavioral detection based on markerless pose tracking

CJ Gabriel, Z Zeidler, B **, C Guo, CM Goodpaster… - Elife, 2022 - elifesciences.org
Quantitative descriptions of animal behavior are essential to study the neural substrates of
cognitive and emotional processes. Analyses of naturalistic behaviors are often performed …

A deep-learning approach for online cell identification and trace extraction in functional two-photon calcium imaging

L Sità, M Brondi, P Lagomarsino de Leon Roig… - Nature …, 2022 - nature.com
In vivo two-photon calcium imaging is a powerful approach in neuroscience. However,
processing two-photon calcium imaging data is computationally intensive and time …

Minian, an open-source miniscope analysis pipeline

Z Dong, W Mau, Y Feng, ZT Pennington, L Chen… - Elife, 2022 - elifesciences.org
Miniature microscopes have gained considerable traction for in vivo calcium imaging in
freely behaving animals. However, extracting calcium signals from raw videos is a …