Mechanism of Candida pathogenesis: revisiting the vital drivers

IE Mba, EI Nweze - European Journal of Clinical Microbiology & Infectious …, 2020 - Springer
Candida is the most implicated fungal pathogen in the clinical setting. Several factors play
important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits …

Candida albicans Heat Shock Proteins and Hsps-Associated Signaling Pathways as Potential Antifungal Targets

Y Gong, T Li, C Yu, S Sun - Frontiers in cellular and infection …, 2017 - frontiersin.org
In recent decades, the incidence of invasive fungal infections has increased notably.
Candida albicans (C. albicans), a common opportunistic fungal pathogen that dwells on …

From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris

S Allert, D Schulz, P Kämmer, P Großmann, T Wolf… - Virulence, 2022 - Taylor & Francis
Candida species are a major cause of invasive fungal infections. While Candida albicans, C.
glabrata, C. parapsilosis, and C. tropicalis are the most dominant species causing life …

[PDF][PDF] Intracellular survival of Candida glabrata in macrophages: immune evasion and persistence

L Kasper, K Seider, B Hube - FEMS Yeast Research, 2015 - academic.oup.com
Candida glabrata is a successful human opportunistic pathogen which causes superficial
but also life-threatening systemic infections. During infection, C. glabrata has to cope with …

Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin

BB Fuchs, R RajaMuthiah, ACR Souza… - Future medicinal …, 2016 - Taylor & Francis
Background: We identified auranofin as an antimicrobial compound utilizing a high-
throughput screen using a Caenorhabditis elegans–Staphylococcus aureus infection model …

Comparative study on alternative splicing in human fungal pathogens suggests its involvement during host invasion

P Sieber, K Voigt, P Kämmer, S Brunke… - Frontiers in …, 2018 - frontiersin.org
Alternative splicing (AS) is an important regulatory mechanism in eukaryotes but only little is
known about its impact in fungi. Human fungal pathogens are of high clinical interest …

Transient mitochondria dysfunction confers fungal cross-resistance against phagocytic killing and fluconazole

S Siscar-Lewin, T Gabaldón, AM Aldejohann, O Kurzai… - MBio, 2021 - Am Soc Microbiol
Loss or inactivation of antivirulence genes is an adaptive strategy in pathogen evolution.
Candida glabrata is an important opportunistic pathogen related to baker's yeast, with the …

Neutrophil activation by Candida glabrata but not Candida albicans promotes fungal uptake by monocytes

S Duggan, F Essig, K Hünniger, Z Mokhtari… - Cellular …, 2015 - Wiley Online Library
C andida albicans and C andida glabrata account for the majority of candidiasis cases
worldwide. Although both species are in the same genus, they differ in key virulence …

The Effectiveness of Voriconazole in Therapy of Candida glabrata's Biofilms Oral Infections and Its Influence on the Matrix Composition and Gene Expression

CF Rodrigues, B Gonçalves, ME Rodrigues, S Silva… - Mycopathologia, 2017 - Springer
Candida glabrata is one of most prevalent yeast in fungal infections, especially in
immunocompromised patients. Its azole resistance results in a low therapeutic response …

Moonlight-like proteins of the cell wall protect sessile cells of Candida from oxidative stress

I Serrano-Fujarte, E López-Romero… - Microbial …, 2016 - Elsevier
Biofilms of Candida species are associated with high morbidity and hospital mortality.
Candida forms biofilms by adhering to human host epithelium through cell wall proteins …