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From imbalance to impairment: the central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration
Increased production and buildup of reactive oxygen species (ROS) can lead to various
health issues, including metabolic problems, cancers, and neurological conditions. Our …
health issues, including metabolic problems, cancers, and neurological conditions. Our …
Metal binding of Alzheimer's amyloid-β and its effect on peptide self-assembly
Conspectus Metal ions have been identified as key factors modulating the aggregation of
amyloid-β peptide (Aβ) implicated in Alzheimer's disease (AD). The presence of elevated …
amyloid-β peptide (Aβ) implicated in Alzheimer's disease (AD). The presence of elevated …
[HTML][HTML] Iron and targeted iron therapy in Alzheimer's disease
J Wang, J Fu, Y Zhao, Q Liu, X Yan, J Su - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide. β-
amyloid plaque (Aβ) deposition and hyperphosphorylated tau, as well as dysregulated …
amyloid plaque (Aβ) deposition and hyperphosphorylated tau, as well as dysregulated …
[HTML][HTML] Redox-active metal ions and amyloid-degrading enzymes in Alzheimer's disease
Redox-active metal ions, Cu (I/II) and Fe (II/III), are essential biological molecules for the
normal functioning of the brain, including oxidative metabolism, synaptic plasticity …
normal functioning of the brain, including oxidative metabolism, synaptic plasticity …
Recent Advances in Targeting Transition Metals (Copper, Iron, and Zinc) in Alzheimer's Disease
Abstract Changes in the transition metal homeostasis in the brain are closely linked with
Alzheimer's disease (AD), including intraneuronal iron accumulation and extracellular …
Alzheimer's disease (AD), including intraneuronal iron accumulation and extracellular …
Brain copper may protect from cognitive decline and Alzheimer's disease pathology: a community-based study
Copper is an essential micronutrient for brain health and dyshomeostasis of copper could
have a pathophysiological role in Alzheimer's disease (AD), however, there are limited data …
have a pathophysiological role in Alzheimer's disease (AD), however, there are limited data …
Evaluation of zinc, copper, and Cu: Zn ratio in serum, and their implications in the course of COVID-19
Background The dynamics of essential metals such as Copper (Cu) and Zinc (Zn) may be
associated with the novel coronavirus disease 2019 (COVID-19) that has spread across the …
associated with the novel coronavirus disease 2019 (COVID-19) that has spread across the …
Dysfunction in atox-1 and ceruloplasmin alters labile Cu levels and consequently Cu homeostasis in C. elegans
AK Weishaupt, K Lamann, E Tallarek… - Frontiers in Molecular …, 2024 - frontiersin.org
Copper (Cu) is an essential trace element, however an excess is toxic due to its redox
properties. Cu homeostasis therefore needs to be tightly regulated via cellular transporters …
properties. Cu homeostasis therefore needs to be tightly regulated via cellular transporters …
Imbalance of essential metals in traumatic brain injury and its possible link with disorders of consciousness
Dysfunction of the complex cerebral networks underlying wakefulness and awareness is
responsible for Disorders of Consciousness (DoC). Traumatic Brain Injury (TBI) is a common …
responsible for Disorders of Consciousness (DoC). Traumatic Brain Injury (TBI) is a common …
Microglia and astrocytes in Alzheimer's disease in the context of the aberrant copper homeostasis hypothesis
Evidence of copper's (Cu) involvement in Alzheimer's disease (AD) is available, but
information on Cu involvement in microglia and astrocytes during the course of AD has yet to …
information on Cu involvement in microglia and astrocytes during the course of AD has yet to …