While oxygen is critical to the continued existence of complex organisms, extreme levels of
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …

microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They
target more than one mRNAs, thus influencing multiple molecular pathways, but also …

microRNAs (miRNAs) are a group of highly conserved small non-coding RNAs that were
found to enhance mRNA degradation or inhibit post-transcriptional translation. Accumulating …

MicroRNAs (miRNAs) are short, noncoding RNAs that posttranscriptionally regulate gene
expression. In the past decade, studies on miRNAs in ovaries have revealed the key roles of …

The effective and efficient management of cancer patients relies upon early diagnosis and/or
the monitoring of treatment, something that is often difficult to achieve using standard tissue …

Hypoxia occurs in the majority of tumours, promoting angiogenesis, metastasis and
resistance to therapy. Responses to hypoxia are orchestrated in part through activation of …

MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as negative gene
expression regulators. In the present study, we investigated miRNAs role in endothelial cell …

Repression of mitochondrial respiration represents an evolutionarily ancient cellular
adaptation to hypoxia and profoundly influences cell survival and function; however, the …

Previous studies have suggested that the HIF transcription factors can both activate and
inhibit gene expression. Here we show that HIF1 regulates the expression of mir-210 in a …

Background—MicroRNAs are involved in various critical functions, including the regulation
of cellular differentiation, proliferation, angiogenesis, and apoptosis. We hypothesize that …