Purpose The hypothalamic–pituitary–adrenal (HPA) axis exerts many actions on the central
nervous system (CNS) aside from stress regulation. Glucocorticoids (GCs) play an important …

Cushing's syndrome (CS) results from chronic exposure to cortisol excess, produced by the
adrenal cortex. Hypercortisolism predisposes to psychiatric and neurocognitive disorders …

This chapter describes regulation of the stress hormones and their measurement and
interpretation in psychophysiological research. A hormone is a signaling molecule, secreted …

Background Neurocognitive impairment in survivors of childhood cancer may be associated
with direct neurotoxicity, as well as indirect effects of systemic health complications. We …

Background Primary adrenal insufficiency (PAI) mortality and morbidity remain unacceptably
high, possibly arising as glucocorticoid replacement does not replicate natural physiology. A …

Sleep is a critical biological process, essential for cognitive well-being. Neuroscientific
literature suggests there are mechanistic relations between sleep disruption and memory …

The steroid hormone cortisol is released in response to stress and exerts its effects in the
brain via two different receptors: the mineralocorticoid receptor (MR) and the glucocorticoid …

In this article, we review published studies covering epidemiology, natural course and
mortality in primary adrenal insufficiency (PAI) or Addison's disease. Autoimmune PAI is a …

Adrenal insufficiency is defined as impaired adrenocortical hormone synthesis. According to
its source, the deficit is classified as primary (adrenal steroidogenesis impairment) …

Patients with salt‐wasting congenital adrenal hyperplasia (SW‐CAH) usually show
pronounced impairment of aldosterone secretion and, therefore, also require …