Pain and analgesia: The dual effect of nitric oxide in the nociceptive system
Y Cury, G Picolo, VP Gutierrez, SH Ferreira - Nitric oxide, 2011 - Elsevier
Nitric oxide (NO) is involved in many physiological processes and several lines of evidence
have indicated that NO plays a complex and diverse role in the modulation of pain. Nitric …
have indicated that NO plays a complex and diverse role in the modulation of pain. Nitric …
Peripheral nitric oxide signaling directly blocks inflammatory pain
Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN)
is the most important mediating mechanism. This mechanism involves direct action of …
is the most important mediating mechanism. This mechanism involves direct action of …
The dual effect of a nitric oxide donor in nociception
Low intrathecal (it) doses of the nitric oxide (NO)-donor 3-morpholinosydnonimine (SIN-
1)(0.1–2.0 μg/10 μl) reduced, while higher doses had no effect (5 or 100 μg/10 μl.) or …
1)(0.1–2.0 μg/10 μl) reduced, while higher doses had no effect (5 or 100 μg/10 μl.) or …
Modulation of opioid actions by nitric oxide signaling.
N Toda, S Kishioka, Y Hatano, H Toda - Anesthesiology, 2009 - europepmc.org
Nitric oxide (NO) plays pivotal roles in controlling physiological functions, participates in
pathophysiological intervention, and is involved in mechanisms underlying beneficial or …
pathophysiological intervention, and is involved in mechanisms underlying beneficial or …
Methanolic Extract of Clinacanthus nutans Exerts Antinociceptive Activity via the Opioid/Nitric Oxide‐Mediated, but cGMP‐Independent, Pathways
MH Abdul Rahim, ZA Zakaria… - Evidence‐Based …, 2016 - Wiley Online Library
The objectives of the present study were to determine the mechanisms of antinociceptive
effect of methanol extract of Clinacanthus nutans (Acanthaceae) leaves (MECN) using …
effect of methanol extract of Clinacanthus nutans (Acanthaceae) leaves (MECN) using …
Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: possible involvements of the L-arginine–NO pathway and opioid system
The present study was undertaken to determine the effects of intracerebroventricular (icv)
and intraperitoneal (ip) melatonin on mechanical allodynia and thermal hyperalgesia in …
and intraperitoneal (ip) melatonin on mechanical allodynia and thermal hyperalgesia in …
Sildenafil-induced peripheral analgesia and activation of the nitric oxide–cyclic GMP pathway
Although several lines of evidence have shown a role of the nitric oxide/cyclic guanosine
monophosphate signaling pathway in the nociceptive mechanism, the exact role of the …
monophosphate signaling pathway in the nociceptive mechanism, the exact role of the …
Participation of the nitric oxide–cyclic GMP–ATP-sensitive K+ channel pathway in the antinociceptive action of ketorolac
GG Lázaro-Ibáñez, JE Torres-López… - European journal of …, 2001 - Elsevier
The involvement of nitric oxide (NO), cyclic GMP and ATP-sensitive K+ channels in the
antinociceptive effect of ketorolac was assessed using the formalin test in the rat. Local …
antinociceptive effect of ketorolac was assessed using the formalin test in the rat. Local …
Nitric oxide and inflammation
There are several pre-clinical studies on the involvement of NO in inflammation. From this
large amount of information it is clear that virtually every cell and many immunological …
large amount of information it is clear that virtually every cell and many immunological …
Magnesium in pain research: state of the art
D Srebro, S Vuckovic, A Milovanovic… - Current medicinal …, 2017 - ingentaconnect.com
Magnesium has been shown to produce an antinociceptive effect on animal models of
neuropathic and inflammatory pain. It has also been shown to exert an analgesic effect on …
neuropathic and inflammatory pain. It has also been shown to exert an analgesic effect on …