No cell lives in a vacuum, and the molecular interactions between cells define most
phenotypes. Transcriptomics provides rich information to infer cell–cell interactions and …

The emergence of drug resistance is the most substantial challenge to the effectiveness of
anticancer therapies. Orthogonal approaches have revealed that a subset of cells, known as …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to
therapies. Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …

Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …

Human tumors are intricate ecosystems composed of diverse genetic clones and malignant
cell states that evolve in a complex tumor micro-environment. Single-cell RNA-sequencing …

Pancreatic cancer is characterized by an extensive fibroinflammatory microenvironment.
During carcinogenesis, normal stromal cells are converted to cytokine-high cancer …

In the past decade, remarkable progress in cancer medicine has been achieved by the
development of treatments that target DNA sequence variants. However, a purely genetic …

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for investigating
cellular biology at an unprecedented resolution, enabling the characterization of cellular …

Embryonic genetic programs are reactivated in response to various types of tissue damage,
providing cell plasticity for tissue regeneration or disease progression. In acute conditions …

Highlights•Tumor-immune CCIs can be investigated using scRNA-seq and ST
strategies.•CCI studies elucidate fundamental mechanisms in disease state.•Open-source …