Antibody-dependent enhancement (ADE) of disease is a general concern for the
development of vaccines and antibody therapies because the mechanisms that underlie …

Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections
and hospitalization in infants under 1 year of age and there is currently no market-approved …

ABSTRACT VIR-7831 and VIR-7832 are dual action monoclonal antibodies (mAbs)
targeting the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS …

The SARS-CoV-2 proteome shares regions of conservation with endemic human
coronaviruses (CoVs), but it remains unknown to what extent these may be cross …

Antibody-dependent cellular cytotoxicity (ADCC) responses to viral infection are a form of
antibody regulated immune responses mediated through the Fc fragment. Whether severe …

COVID-19 (SARS-CoV-2) disease severity and stages varies from asymptomatic, mild flu-
like symptoms, moderate, severe, critical, and chronic disease. COVID-19 disease …

Influenza is an acute respiratory disease in mammals and domestic poultry that emerges
from zoonotic reservoirs in aquatic birds and bats. Although influenza viruses are among the …

Vaccination is the most effective method to prevent influenza infection. However, current
influenza vaccines have several limitations. Relatively long production times, limited vaccine …

Sensitization of the humoral immune response to invading viruses and production of
antiviral antibodies forms part of the host antiviral repertoire. Paradoxically, for a number of …

Influenza virus infection is an ongoing health and economic burden causing epidemics with
pandemic potential, affecting 5–30% of the global population annually, and is responsible …