Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

The molecular biology of FMRP: new insights into fragile X syndrome

JD Richter, X Zhao - Nature Reviews Neuroscience, 2021 - nature.com
Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …

A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies

Y Kang, Y Zhou, Y Li, Y Han, J Xu, W Niu, Z Li… - Nature …, 2021 - nature.com
Fragile X syndrome (FXS) is caused by the loss of fragile X mental retardation protein
(FMRP), an RNA-binding protein that can regulate the translation of specific mRNAs. In this …

Exon-intron circular RNAs regulate transcription in the nucleus

Z Li, C Huang, C Bao, L Chen, M Lin, X Wang… - Nature structural & …, 2015 - nature.com
Noncoding RNAs (ncRNAs) have numerous roles in development and disease, and one of
the prominent roles is to regulate gene expression. A vast number of circular RNAs …

Adult neurogenesis in the mammalian brain: significant answers and significant questions

G Ming, H Song - Neuron, 2011 - cell.com
Adult neurogenesis, a process of generating functional neurons from adult neural
precursors, occurs throughout life in restricted brain regions in mammals. The past decade …

Altered neuronal and circuit excitability in fragile X syndrome

A Contractor, VA Klyachko, C Portera-Cailliau - Neuron, 2015 - cell.com
Fragile X syndrome (FXS) results from a genetic mutation in a single gene yet produces a
phenotypically complex disorder with a range of neurological and psychiatric problems …

Functions and dysfunctions of adult hippocampal neurogenesis

KM Christian, H Song, G Ming - Annual review of neuroscience, 2014 - annualreviews.org
Adult neurogenesis, a developmental process of generating functionally integrated neurons,
occurs throughout life in the hippocampus of the mammalian brain and showcases the …

Signaling mechanisms regulating adult neural stem cells and neurogenesis

R Faigle, H Song - Biochimica et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: Adult neurogenesis occurs throughout life in discrete regions of the
mammalian brain and is tightly regulated via both extrinsic environmental influences and …

Exosomes and their therapeutic potentials of stem cells

C Han, X Sun, L Liu, H Jiang, Y Shen, X Xu… - Stem cells …, 2016 - Wiley Online Library
Exosomes, a group of vesicles originating from the multivesicular bodies (MVBs), are
released into the extracellular space when MVBs fuse with the plasma membrane …

Wnt/β-catenin-dependent transcription in autism spectrum disorders

MO Caracci, ME Avila… - Frontiers in molecular …, 2021 - frontiersin.org
Autism spectrum disorders (ASD) is a heterogeneous group of neurodevelopmental
disorders characterized by synaptic dysfunction and defects in dendritic spine morphology …