Small-molecule fluorescent probes for binding-and activity-based sensing of redox-active biological metals

K Grover, A Koblova, AT Pezacki, CJ Chang… - Chemical …, 2024 - ACS Publications
Although transition metals constitute less than 0.1% of the total mass within a human body,
they have a substantial impact on fundamental biological processes across all kingdoms of …

Fluorescent probes for the detection of disease-associated biomarkers

WT Dou, HH Han, AC Sedgwick, GB Zhu, Y Zang… - Science Bulletin, 2022 - Elsevier
Fluorescent probes have emerged as indispensable chemical tools to the field of chemical
biology and medicine. The ability to detect intracellular species and monitor physiological …

Solution-based Cu+ transient species mediate the reconstruction of copper electrocatalysts for CO2 reduction

J Vavra, GPL Ramona, F Dattila, A Kormányos… - Nature Catalysis, 2024 - nature.com
Understanding metal surface reconstruction is of the utmost importance in electrocatalysis,
as this phenomenon directly affects the nature of available active sites. However, its dynamic …

Inverse electron demand Diels–Alder reactions in chemical biology

BL Oliveira, Z Guo, GJL Bernardes - Chemical Society Reviews, 2017 - pubs.rsc.org
The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other
bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and …

Mitochondria-targeted fluorophore: State of the art and future trends

Q Ding, X Wang, Y Luo, X Leng, X Li, M Gu… - Coordination Chemistry …, 2024 - Elsevier
Mitochondria, pivotal organelles responsible for cellular energy production and behavioral
regulation, play a crucial role in various diseases, notably cancer. Mitochondria-targeting …

Design strategies for water-soluble small molecular chromogenic and fluorogenic probes

X Li, X Gao, W Shi, H Ma - Chemical reviews, 2014 - ACS Publications
Chromogenic and fluorogenic probes may be described as the reagents that can interact
with analytes (targets) accompanied by the changes of their spectroscopic (chromogenic, or …

Activity‐based sensing: a synthetic methods approach for selective molecular imaging and beyond

KJ Bruemmer, SWM Crossley… - Angewandte Chemie …, 2020 - Wiley Online Library
Emerging from the origins of supramolecular chemistry and the development of selective
chemical receptors that rely on lock‐and‐key binding, activity‐based sensing (ABS)—which …

Drosophila immune cells transport oxygen through PPO2 protein phase transition

M Shin, E Chang, D Lee, N Kim, B Cho, N Cha… - Nature, 2024 - nature.com
Insect respiration has long been thought to be solely dependent on an elaborate tracheal
system without assistance from the circulatory system or immune cells,. Here we describe …

Reaction-based small-molecule fluorescent probes for chemoselective bioimaging

J Chan, SC Dodani, CJ Chang - Nature chemistry, 2012 - nature.com
The dynamic chemical diversity of elements, ions and molecules that form the basis of life
offers both a challenge and an opportunity for study. Small-molecule fluorescent probes can …

Multimetallic transition metal complexes: Luminescent probes for biomolecule sensing, ion detection, imaging and therapeutic application

B Das, P Gupta - Coordination Chemistry Reviews, 2024 - Elsevier
In the past decade, luminescent multimetallic transition metal complexes have become
indispensable tools in biology. They enable versatile applications, detecting biomolecules …