Recent trends in miRNA therapeutics and the application of plant miRNA for prevention and treatment of human diseases

AN Saiyed, AR Vasavada, SRK Johar - Future Journal of Pharmaceutical …, 2022 - Springer
Background Researchers now have a new avenue to investigate when it comes to miRNA-
based therapeutics. miRNAs have the potential to be valuable biomarkers for disease …

[HTML][HTML] MicroRNAs in medicinal plants

M Sun, S Xu, Y Mei, J Li, Y Gu, W Zhang… - International journal of …, 2022 - mdpi.com
Medicinal plant microRNAs (miRNAs) are an endogenous class of small RNA central to the
posttranscriptional regulation of gene expression. Biosynthetic research has shown that the …

Computational identification of miRNA and their cross kingdom targets from expressed sequence tags of Ocimum basilicum

M Patel, N Mangukia, N Jha, H Gadhavi, K Shah… - Molecular biology …, 2019 - Springer
MicroRNAs (miRNAs) are conserved small non coding RNAs, which are typically 22–24
nucleotides long and play an important role in post transcription regulation andin various …

[HTML][HTML] Soybean-derived miRNAs specifically inhibit proliferation and stimulate apoptosis of human colonic Caco-2 cancer cells but not normal mucosal cells in …

J Liu, F Wang, Z Weng, X Sui, Y Fang, X Tang, X Shen - Genomics, 2020 - Elsevier
MicroRNAs (miRNAs) are important regulators of gene expression in eukaryotes. Studies
have shown that plant-derived miRNAs can be absorbed through diets and regulate gene …

Transcriptome-wide miRNA identification of Bacopa monnieri: a cross-kingdom approach

H Gadhavi, M Patel, N Mangukia, K Shah… - Plant Signaling & …, 2020 - Taylor & Francis
Bacopa monnieri known as LBrahmiL is a well-known medicinal plant belonging to
Scrophulariaceae family for its nootropic properties. To the best of our knowledge, no …

Small RNA sequencing and identification of papaya (Carica papaya L.) miRNAs with potential cross-kingdom human gene targets

N Jha, N Mangukia, H Gadhavi, M Patel… - Molecular Genetics and …, 2022 - Springer
Several studies have demonstrated potential role of plant-derived miRNAs in cross-kingdom
species relationships by transferring into non-plant host cells to regulate certain host cellular …

Targeting Metabolic Syndrome Pathways: Carrot microRNAs As Potential Modulators

EE Reza-Zaldívar, DA Jacobo-Velázquez - ACS omega, 2024 - ACS Publications
Metabolic syndrome is a condition characterized by metabolic alterations that culminate in
chronic noncommunicable diseases of high morbidity and mortality, such as cardiovascular …

Targeting Bone Metastases Signaling Pathway Using Moringa oleifera Seed Nutri-miRs: A Cross Kingdom Approach

K Bhadresha, M Patel, J Brahmbhatt, N Jain… - Nutrition and …, 2022 - Taylor & Francis
Moringa oleifera is a medicinally important plant that has various medical and nutritional
uses. Plant miRNAs are a class of non-coding endogenous small RNAs that regulate human …

Exploring the MiRnome of Carica papaya: a cross kingdom approach

N Jha, N Mangukia, MP Patel, M Bhavsar, H Gadhavi… - Gene Reports, 2021 - Elsevier
Carica papaya is a native fruit with high nutraceutical value that also has potential
therapeutic properties. However, the human diet plays an important role in the prevention of …

OLFML2A Overexpression Predicts an Unfavorable Prognosis in Patients with AML

X Lu, Y Li, Y Yang, W Zhuang, X Chai… - Journal of …, 2023 - Wiley Online Library
Background. Acute myeloid leukemia (AML) is a malignant clonal disease of the myeloid
hematopoietic system. Clinically, standard treatment options include conventional …