Somatostatin and its receptor family

YC Patel - Frontiers in neuroendocrinology, 1999 - Elsevier
Somatostatin (SST), a regulatory peptide, is produced by neuroendocrine, inflammatory, and
immune cells in response to ions, nutrients, neuropeptides, neurotransmitters, thyroid and …

Peptide receptors as molecular targets for cancer diagnosis and therapy

JC Reubi - Endocrine reviews, 2003 - academic.oup.com
During the past decade, proof of the principle that peptide receptors can be used
successfully for in vivo targeting of human cancers has been provided. The molecular basis …

The cells of the islets of Langerhans

G Da Silva Xavier - Journal of clinical medicine, 2018 - mdpi.com
Islets of Langerhans are islands of endocrine cells scattered throughout the pancreas. A
number of new studies have pointed to the potential for conversion of non-β islet cells in to …

Systemic complications of acromegaly and the impact of the current treatment landscape: an update

MR Gadelha, L Kasuki, DST Lim… - Endocrine reviews, 2019 - academic.oup.com
Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

The new biology and pharmacology of glucagon

TD Müller, B Finan, C Clemmensen… - Physiological …, 2017 - journals.physiology.org
In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

Somatostatin receptor sst1–sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands

J Reubi, B Waser, JC Schaer, JA Laissue - European journal of nuclear …, 2001 - Springer
Somatostatin receptors are known to be expressed in a large number of human tumours and
represent the basis for in vivo tumour targeting. Stable somatostatin derivatives such as …

Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity

M Rocheville, DC Lange, U Kumar, SC Patel, RC Patel… - Science, 2000 - science.org
Somatostatin and dopamine are two major neurotransmitter systems that share a number of
structural and functional characteristics. Somatostatin receptors and dopamine receptors are …

α-Cells of the endocrine pancreas: 35 years of research but the enigma remains

J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - academic.oup.com
Glucagon, a hormone secreted from the α-cells of the endocrine pancreas, is critical for
blood glucose homeostasis. It is the major counterpart to insulin and is released during …

Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes

I Quesada, E Tudurí, C Ripoll… - Journal of …, 2008 - joe.bioscientifica.com
Angiogenesis is an important component in the development of thyroid goitre. Vascular
endothelial growth factor (VEGF) represents a family of specific endothelial cell mitogens …

Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours

I Buchmann, M Henze, S Engelbrecht… - European journal of …, 2007 - Springer
Abstract Purpose Neuroendocrine tumours (NETs) can be imaged with scintigraphy using
radiolabelled somatostatin analogues. The aim of our study was to compare the value of 68 …