The axon initial segment: an updated viewpoint
C Leterrier - Journal of Neuroscience, 2018 - Soc Neuroscience
At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …
AIS generates and shapes the action potential before it is propagated along the axon …
CaMKII in myocardial hypertrophy and heart failure
Many signals have risen and fallen in the tide of investigation into mechanisms of
myocardial hypertrophy and heart failure (HF). In our opinion, the multifunctional Ca and …
myocardial hypertrophy and heart failure (HF). In our opinion, the multifunctional Ca and …
Mechanisms of Altered Ca2+ Handling in Heart Failure
M Luo, ME Anderson - Circulation research, 2013 - Am Heart Assoc
Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …
myocardium. The hallmark features of heart failure are mechanical dysfunction and …
Mitochondrial reactive oxygen species production and elimination
A Nickel, M Kohlhaas, C Maack - Journal of molecular and cellular …, 2014 - Elsevier
Reactive oxygen species (ROS) play an important role in cardiovascular diseases, and one
important source for ROS are mitochondria. Emission of ROS from mitochondria is the net …
important source for ROS are mitochondria. Emission of ROS from mitochondria is the net …
Calmodulin-dependent protein kinase II: linking heart failure and arrhythmias
PD Swaminathan, A Purohit, TJ Hund… - Circulation …, 2012 - Am Heart Assoc
Understanding relationships between heart failure and arrhythmias, important causes of
suffering and sudden death, remains an unmet goal for biomedical researchers and …
suffering and sudden death, remains an unmet goal for biomedical researchers and …
CaMKII inhibitors: from research tools to therapeutic agents
P Pellicena, H Schulman - Frontiers in pharmacology, 2014 - frontiersin.org
The cardiac field has benefited from the availability of several CaMKII inhibitors serving as
research tools to test putative CaMKII pathways associated with cardiovascular physiology …
research tools to test putative CaMKII pathways associated with cardiovascular physiology …
Cardioprotection by SGLT2 Inhibitors—Does It All Come Down to Na+?
M Trum, J Riechel, S Wagner - International Journal of Molecular …, 2021 - mdpi.com
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are emerging as a new treatment
strategy for heart failure with reduced ejection fraction (HFrEF) and—depending on the …
strategy for heart failure with reduced ejection fraction (HFrEF) and—depending on the …
Reactive Oxygen Species–Activated Ca/Calmodulin Kinase IIδ Is Required for Late INa Augmentation Leading to Cellular Na and Ca Overload
S Wagner, HM Ruff, SL Weber, S Bellmann… - Circulation …, 2011 - Am Heart Assoc
Rationale: In heart failure Ca/calmodulin kinase (CaMK) II expression and reactive oxygen
species (ROS) are increased. Both ROS and CaMKII can increase late I Na leading to …
species (ROS) are increased. Both ROS and CaMKII can increase late I Na leading to …
Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc
PY Sato, W Coombs, X Lin, O Nekrasova… - Circulation …, 2011 - Am Heart Assoc
Rationale: The early description of the intercalated disc defined 3 structures, all of them
involved in cell-cell communication: desmosomes, gap junctions, and adherens junctions …
involved in cell-cell communication: desmosomes, gap junctions, and adherens junctions …
Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited
cardiac arrhythmia characterized by adrenergically triggered arrhythmias, is inadequately …
cardiac arrhythmia characterized by adrenergically triggered arrhythmias, is inadequately …