Intermediate filaments (IFs) are assembled from a diverse group of evolutionarily conserved
proteins and are specified in a tissue-dependent, cell type-dependent, and context …

Adherens junctions, which are intercellular adhesive complexes that are crucial for
maintaining epithelial homeostasis, are downregulated in many cancers to promote tumour …

Lipocalin 2 is a siderophore‐binding protein that regulates iron homeostasis. Lipocalin 2
expression is elevated in multiple tumor types; however, the mechanisms that drive tumor …

Keratins are cytoplasmic intermediate filament proteins preferentially expressed by epithelial
tissues in a site-specific and differentiation-dependent manner. The complex network of …

Cell junctions are sites of intercellular adhesion that maintain the integrity of epithelial tissue
and regulate signalling between cells. These adhesive junctions are comprised of protein …

Armadillo family proteins known as plakophilins have been characterized as structural
components of desmosomes that stabilize and strengthen adhesion by enhancing …

Cell aggregation is frequently impaired during the growth of primary tumors and the
formation of metastatic lesions. Cell aggregation depends on cell–cell adhesion; however …

Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities
that affect sites of cell-cell contact can cause a variety of debilitating disorders. The …

Growth of skeletal and cardiac muscles, like that of dividing cells, is largely dependent on
signaling through the insulin–PI3K–Akt–FoxO pathway. Conversely, the atrophy of specific …

Decreased intercellular adhesion is a key step in the metastasis and recurrence of many
cancers, including hepatocellular carcinoma (HCC). SVEP1 is an important cell adhesion …