Polyketide biosynthesis: a millennium review - Natural Product Reports (RSC Publishing)
DOI:10.1039/A909079G Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article …

Covering: up to September 2009 This review covers the recent literature on the release
mechanisms for polyketides and nonribosomal peptides produced by microorganisms. The …

Erythromycin and rapamycin are both macrolide antibiotics. 1, 2 Erythromycin A (1) belongs
to a large family of macrolides which are characterized by rings containing 12, 14, or 16 …

Aromatic and complex polyketides are produced by the condensation of carboxylic acids.
They exhibit antibacterial, antifungal and anthelmintic properties and are produced by fungi …

Macrocyclic polyketides exhibit an impressive range of medically useful activities, and there
is great interest in manipulating the genes that govern their synthesis. The 6 …

Abstract Background: Modular polyketide synthases (PKSs) function as molecular assembly
lines in which polyketide chains are assembled by successive addition of chain extension …

Background Polyketides are important compounds with antibiotic and anticancer activities.
Several modular polyketide synthases (PKSs) contain a terminal thioesterase (TE) domain …

Sequencing of the eryA region of the erythromycin biosynthetic gene cluster from
Saccharopolyspora erythraea has revealed another structural gene (ORF B), in addition to …

Background EntF is a 142 kDa four domain (condensation-adenylationpeptidyl carrier
protein-thioesterase) nonribosomal peptide synthetase (NRPS) enzyme that assembles the …

Background: Polyene macrolides are a class of large macrocyclic polyketides that interact
with membrane sterols, having antibiotic activity against fungi but not bacteria. Their rings …