A guide to the organ-on-a-chip
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
A critical perspective on 3D liver models for drug metabolism and toxicology studies
The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …
3D and organoid culture in research: physiology, hereditary genetic diseases and cancer
E Suarez-Martinez, I Suazo-Sanchez, M Celis-Romero… - Cell & Bioscience, 2022 - Springer
In nature, cells reside in tissues subject to complex cell–cell interactions, signals from
extracellular molecules and niche soluble and mechanical signaling. These …
extracellular molecules and niche soluble and mechanical signaling. These …
Recent advances in organoid engineering: A comprehensive review
Organoid, a 3D structure derived from various cell sources including progenitor and
differentiated cells that self-organize through cell-cell and cell-matrix interactions to …
differentiated cells that self-organize through cell-cell and cell-matrix interactions to …
Continuous production of highly functional vascularized hepatobiliary organoids from human pluripotent stem cells using a scalable microfluidic platform
Abstract “Organoid medicine” has rapidly progressed over the past decade as a new class of
therapeutics with high functionality and complexity for addressing unmet medical needs …
therapeutics with high functionality and complexity for addressing unmet medical needs …
A hydrogel–fiber–hydrogel composite scaffold based on silk fibroin with the dual‐delivery of oxygen and quercetin
Supplying sufficient oxygen within the scaffolds is one of the essential hindrances in tissue
engineering that can be resolved by oxygen‐generating biomaterials (OGBs). Two main …
engineering that can be resolved by oxygen‐generating biomaterials (OGBs). Two main …
Revealing the clinical potential of high-resolution organoids
The symbiotic interplay of organoid technology and advanced imaging strategies yields
innovative breakthroughs in research and clinical applications. Organoids, intricate three …
innovative breakthroughs in research and clinical applications. Organoids, intricate three …
Cell culture process scale-up challenges for commercial-scale manufacturing of allogeneic pluripotent stem cell products
Allogeneic cell therapy products, such as therapeutic cells derived from pluripotent stem
cells (PSCs), have amazing potential to treat a wide variety of diseases and vast numbers of …
cells (PSCs), have amazing potential to treat a wide variety of diseases and vast numbers of …
Balance between the Cell Viability and Death in 3D
Cell death is a phenomenon, frequently perceived as an absolute event for cell, tissue and
the organ. However, the rising popularity and complexity of such 3D multicellular 'tissue …
the organ. However, the rising popularity and complexity of such 3D multicellular 'tissue …
Oxygen control in bioreactor drives high yield production of functional hiPSC-like hepatocytes for advanced liver disease modelling
P Vicente, JI Almeida, IE Crespo, N Virgolini… - Scientific Reports, 2024 - nature.com
Hepatocytes-like cells (HLC) derived from human induced pluripotent stem cells show great
promise for cell-based liver therapies and disease modelling. However, their application is …
promise for cell-based liver therapies and disease modelling. However, their application is …