Prospects and challenges of dynamic DNA nanostructures in biomedical applications

T Tian, Y Li, Y Lin - Bone Research, 2022 - nature.com
The physicochemical nature of DNA allows the assembly of highly predictable structures via
several fabrication strategies, which have been applied to make breakthroughs in various …

Design and simulation of DNA, RNA and hybrid protein–nucleic acid nanostructures with oxView

J Bohlin, M Matthies, E Poppleton, J Procyk, A Mallya… - Nature protocols, 2022 - nature.com
Molecular simulation has become an integral part of the DNA/RNA nanotechnology
research pipeline. In particular, understanding the dynamics of structures and single …

DNA-based programmable gate arrays for general-purpose DNA computing

H Lv, N ** of arbitrary 2D and 3D wireframe DNA origami
H Jun, X Wang, MF Parsons, WP Bricker… - Nucleic acids …, 2021 - academic.oup.com
Wireframe DNA origami assemblies can now be programmed automatically from the top-
down using simple wireframe target geometries, or meshes, in 2D and 3D, using either rigid …

OxDNA. org: a public webserver for coarse-grained simulations of DNA and RNA nanostructures

E Poppleton, R Romero, A Mallya… - Nucleic acids …, 2021 - academic.oup.com
OxDNA and oxRNA are popular coarse-grained models used by the DNA/RNA
nanotechnology community to prototype, analyze and rationalize designed DNA and RNA …

A lumen-tunable triangular DNA nanopore for molecular sensing and cross-membrane transport

X Liu, F Liu, H Chhabra, C Maffeo, Z Chen… - Nature …, 2024 - nature.com
Synthetic membrane nanopores made of DNA are promising systems to sense and control
molecular transport in biosensing, sequencing, and synthetic cells. Lumen-tunable …

A primer on the oxDNA model of DNA: when to use it, how to simulate it and how to interpret the results

A Sengar, TE Ouldridge, O Henrich… - Frontiers in Molecular …, 2021 - frontiersin.org
The oxDNA model of Deoxyribonucleic acid has been applied widely to systems in biology,
biophysics and nanotechnology. It is currently available via two independent open source …

Determining sequence-dependent DNA oligonucleotide hybridization and dehybridization mechanisms using coarse-grained molecular simulation, markov state …

MS Jones, B Ashwood, A Tokmakoff… - Journal of the …, 2021 - ACS Publications
A robust understanding of the sequence-dependent thermodynamics of DNA hybridization
has enabled rapid advances in DNA nanotechnology. A fundamental understanding of the …

Planar 2D wireframe DNA origami

X Wang, S Li, H Jun, T John, K Zhang, H Fowler… - Science …, 2022 - science.org
Two-dimensional (2D) DNA origami is widely used for applications ranging from excitonics
to single-molecule biophysics. Conventional, single-layer 2D DNA origami exhibits flexibility …