Hamster models of COVID-19 pneumonia reviewed: How human can they be?
The dramatic global consequences of the coronavirus disease 2019 (COVID-19) pandemic
soon fueled quests for a suitable model that would facilitate the development and testing of …
soon fueled quests for a suitable model that would facilitate the development and testing of …
[HTML][HTML] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection
SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …
Passive immunotherapy against SARS-CoV-2: from plasma-based therapy to single potent antibodies in the race to stay ahead of the variants
The COVID-19 pandemic is now approaching 2 years old, with more than 440 million people
infected and nearly six million dead worldwide, making it the most significant pandemic …
infected and nearly six million dead worldwide, making it the most significant pandemic …
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging …
immune protection is not fully understood. Here, we applied live bioluminescence imaging …
SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for spillback to New World rodents
Coronavirus disease-19 (COVID-19) emerged in late 2019 in China and rapidly became
pandemic. As with other coronaviruses, a preponderance of evidence suggests the virus …
pandemic. As with other coronaviruses, a preponderance of evidence suggests the virus …
A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope
With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants with increased transmissibility and potential resistance, antibodies and vaccines …
variants with increased transmissibility and potential resistance, antibodies and vaccines …
A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies
As a result of the SARS-CoV-2 pandemic numerous scientific groups have generated
antibodies against a single target: the CoV-2 spike antigen. This has provided an …
antibodies against a single target: the CoV-2 spike antigen. This has provided an …
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics
For coronavirus disease 2019 (COVID-19), effective and well-understood treatment options
are still scarce. Since vaccine efficacy is challenged by novel variants, short-lasting …
are still scarce. Since vaccine efficacy is challenged by novel variants, short-lasting …
In Silico Analyses on the Comparative Potential of Therapeutic Human Monoclonal Antibodies Against Newly Emerged SARS-CoV-2 Variants Bearing Mutant Spike …
Since the start of the pandemic, SARS-CoV-2 has already infected more than 250 million
people globally, with more than five million fatal cases and huge socio-economic losses. In …
people globally, with more than five million fatal cases and huge socio-economic losses. In …
COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models
Abstract Effective treatments against Severe Acute Respiratory Syndrome coronavirus 2
(SARS-CoV-2) are urgently needed. Monoclonal antibodies have shown promising results …
(SARS-CoV-2) are urgently needed. Monoclonal antibodies have shown promising results …