NAFLD in the 21st century: current knowledge regarding its pathogenesis, diagnosis and therapeutics

D Kounatidis, NG Vallianou, E Geladari, MP Panoilia… - Biomedicines, 2024 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a major public health issue worldwide. It is the
most common liver disease in Western countries, andits global prevalence is estimated to be …

Effects and potential mechanisms of IGF1/IGF1R in the liver fibrosis: A review

R Gui, W Li, Z Li, H Wang, Y Wu, W Jiao, G Zhao… - International journal of …, 2023 - Elsevier
Liver fibrosis is a wound-healing response due to persistent liver damage and it may
progress to cirrhosis and even liver cancer if no intervention is given. In the current …

Alantolactone attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease

J Wang, Y Jiang, L **, C Qian, W Zuo, J Lin, L **e… - Nutrition & …, 2024 - nature.com
Background Nonalcoholic fatty liver disease (NAFLD) is a chronic disease with an
increasing incidence, which can further develop into liver fibrosis and hepatocellular …

Metabolic Dysfunction-Associated Steatotic Liver Disease in a Dish: Human Precision-Cut Liver Slices as a Platform for Drug Screening and Interventions

M Li, FT Larsen, MC van den Heuvel, K Gier, AR Gorter… - Nutrients, 2024 - mdpi.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing healthcare
problem with limited therapeutic options. Progress in this field depends on the availability of …

Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells

H Zhou, Y Liu, Y Su, P Ji, L Kong, R Sun… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Ginseng (Panax ginseng CA Meyer) is a precious
traditional Chinese medicine with multiple pharmacological effects. Ginsenoside Rg1 is a …

Phillygenin inhibits TGF-β1-induced hepatic stellate cell activation and inflammation: Regulation of the Bax/Bcl-2 and Wnt/β-catenin pathways

C Wang, S Zhang, Y Li, L Gong, C Yao, K Fu, Y Li - Inflammation, 2024 - Springer
Hepatic fibrosis (HF), a precursor to cirrhosis and hepatocellular carcinoma, is caused by
abnormal proliferation of connective tissue and excessive accumulation of extracellular …

Effects of a Two-Year Lifestyle Intervention on Intrahepatic Fat Reduction and Renal Health: Mitigation of Inflammation and Oxidative Stress, a Randomized Trial

MM Quetglas-Llabrés, M Monserrat-Mesquida… - Antioxidants, 2024 - mdpi.com
Metabolic-associated fatty liver disease (MAFLD) is the most common chronic liver disease
observed in clinical practice worldwide. This disorder has been independently associated …

Thrombospondin 2 is a key determinant of fibrogenesis in non‐alcoholic fatty liver disease

T Kimura, T Iwadare, S Wakabayashi… - Liver …, 2024 - Wiley Online Library
Objective Hepatic overexpression of the thrombospondin 2 gene (THBS2) and elevated
levels of circulating thrombospondin 2 (TSP2) have been observed in patients with chronic …

TGF Beta as a Prognostic Biomarker of COVID-19 Severity in Patients with NAFLD—A Prospective Case–Control Study

F Susak, N Vrsaljko, A Vince, N Papic - Microorganisms, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD), the leading cause of chronic liver disease in
Western countries, has been identified as a possible risk factor for COVID-19 severity …

Roles of transforming growth factor-β signaling in liver disease

XL Wang, M Yang, Y Wang - World journal of hepatology, 2024 - pmc.ncbi.nlm.nih.gov
In this editorial we expand the discussion on the article by Zhang et al published in the
recent issue of the World Journal of Hepatology. We focus on the diagnostic and therapeutic …