Injectable anti‐inflammatory supramolecular nanofiber hydrogel to promote anti‐VEGF therapy in age‐related macular degeneration treatment

H Gao, M Chen, Y Liu, D Zhang, J Shen… - Advanced …, 2023 - Wiley Online Library
Age‐related macular degeneration (AMD) is a major cause of visual impairment and severe
vision loss worldwide, while the currently available treatments are often unsatisfactory …

Review of nutrient actions on age-related macular degeneration

S Zampatti, F Ricci, A Cusumano, LT Marsella… - Nutrition research, 2014 - Elsevier
The actions of nutrients and related compounds on age-related macular degeneration
(AMD) are explained in this review. The findings from 80 studies published since 2003 on …

Towards the application of precision medicine in Age-Related Macular Degeneration

R Cascella, C Strafella, V Caputo, V Errichiello… - Progress in Retinal and …, 2018 - Elsevier
The review essentially describes genetic and non-genetic variables contributing to the onset
and progression of exudative Age-related Macular Degeneration (AMD) in Italian …

Age‐related macular degeneration: insights into inflammatory genes

R Cascella, M Ragazzo, C Strafella… - Journal of …, 2014 - Wiley Online Library
Age‐related macular degeneration (AMD) is a progressive neurodegenerative disease that
affects approximately 8.7% of elderly people worldwide (> 55 years old). AMD is …

A randomized study of nutritional supplementation in patients with unilateral wet age-related macular degeneration

A García-Layana, S Recalde, M Hernandez… - Nutrients, 2021 - mdpi.com
The purpose of this study is evaluate the efficacy and safety of medicinal products containing
the original Age-Related Eye Disease group (AREDS) formulation at doses approved in …

Peripheral blood mononuclear cells from neovascular age-related macular degeneration patients produce higher levels of chemokines CCL2 (MCP-1) and CXCL8 (IL …

J Lechner, M Chen, RE Hogg, L Toth, G Silvestri… - Journal of …, 2017 - Springer
Background Infiltrating immune cells including monocytes/macrophages have been
implicated in the pathogenesis of neovascular age-related macular degeneration (nAMD) …

[HTML][HTML] Mitochondrial DNA has a pro-inflammatory role in AMD

B Dib, H Lin, DE Maidana, B Tian, JB Miller… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
the elderly of industrialized nations, and there is increasing evidence to support a role for …

[HTML][HTML] A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells

VM Parmar, T Parmar, E Arai, L Perusek, A Maeda - Stem cell research, 2018 - Elsevier
Accumulation of lipofuscin in the retinal pigmented epithelium (RPE) is observed in retinal
degenerative diseases including Stargardt disease and age-related macular degeneration …

Uncovering genetic and non-genetic biomarkers specific for exudative age-related macular degeneration: significant association of twelve variants

R Cascella, C Strafella, G Longo, M Ragazzo… - …, 2017 - pmc.ncbi.nlm.nih.gov
Age-related Macular Degeneration (AMD) represents one of the most sight-threatening
diseases in developed countries that substantially impacts the patients' lifestyle by …

In vitro maturation of retinal pigment epithelium is essential for maintaining high expression of key functional genes

A Al-Ani, S Sunba, B Hafeez, D Toms… - International journal of …, 2020 - mdpi.com
Age-related macular degeneration (AMD) is the leading cause of blindness in the
industrialized world. AMD is associated with dysfunction and atrophy of the retinal pigment …