Target-based drug discovery is the dominant paradigm of drug discovery; however, a
comprehensive evaluation of its real-world efficiency is lacking. Here, a manual systematic …

Several Dinophysis species produce diarrhoetic toxins (okadaic acid and dinophysistoxins)
and pectenotoxins, and cause gastointestinal illness, Diarrhetic Shellfish Poisoning (DSP) …

Halichondrins—antitumor polyether macrolides Page 1 Pure & App!. Chem., Vol. 58, No. 5,
pp. 701—710, 1986. Printed in Great Britain. © 1986 IUPAC Halichondrins—antitumor …

Marine toxins have drawn scientists' attention due to their involvement in human intoxication
and the socioeconomic impactsbrought by those incidents. Elucidation of chemical …

The oceans are the source of a large group of structurally unique natural products that are
mainly accumulated in invertebrates such as sponges, tunicates, bryozoans, and molluscs …

Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is
easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be …

Calyculin A and okadaic acid induce contraction in smooth muscle fibers. Okadaic acid is an
inhibitor of phosphatase activity and the aims of this study were to determine if calyculin A …

Metabolites from symbiotic bacteria - Natural Product Reports (RSC Publishing) DOI:10.1039/B703499G
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B703499G …

Spiroketals1 enjoy widespread occurrence as sub-structures of naturally occurring
substances from many sources, including insects, microbes, plants, fungi, and marine …

As the causative agents of a new type of shellfish poisoning, named diarrhetic shellfish
poisoning, okadaic acid, 35 (S)-methylokadaic acid, 7-O-acyl derivatives of 35 (S) …