Isoniazid (INH) is one of the most active compounds used to treat tuberculosis (TB)
worldwide. In addition, INH has been used as a prophylactic drug for individuals with latent …

Tuberculosis (TB) chemotherapy started in the 1930s with the discovery by Domagk and
colleagues of the anti‐TB activity of sulfonamides. Since these compounds were very toxic …

Drug resistance in tuberculosis (TB) is a particular problem because the lengthy therapy of
at least 6 months makes patient compliance very difficult, which frequently creates drug …

Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …

Isoniazid (INH) is a central component of drug regimens used worldwide to treat
tuberculosis. Previous studies have identified resistance-associated mutations in katG, inhA …

Isoniazid (INH) is one of the most efficient drugs for the treatment of Mycobacterium
tuberculosis infections. Despite its rather simple chemical structure, the mechanism by which …

Arylamine N‐acetyltransferases (NAT s) are polymorphic drug‐metabolizing enzymes,
acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides …

Background: Whole-genome sequencing (WGS) is a viable and financially feasible tool for
timely and comprehensive diagnosis of drug resistance in developed countries. With the …

Tuberculosis is the leading cause of death from a curable infectious disease and there were
an estimated 8.9 million new cases of tuberculosis in 2004 [1]. Tackling the global burden of …

For over half a century, pyridine-4-carboxy hydrazide (isonicotinyl hydrazide; isoniazid-INH)
has been a front-line weapon in the battle against tuberculosis. Its metabolism has been the …