Venomous animals have evolved toxins that interfere with specific components of their
victim's core physiological systems, thereby causing biological dysfunction that aids in prey …

Tissue acidification is associated with a variety of disease states, and acid-sensing ion
channels (ASICs) that can sense changes in pH have gained traction as possible …

Sea anemones produce venoms of exceptional molecular diversity, with at least 17 different
molecular scaffolds reported to date. These venom components have traditionally been …

Spiders have been evolving complex and diverse repertoires of peptides in their venoms
with vast pharmacological activities for more than 300 million years. Spiders use their …

Venomous animals on the earth have been found to be valuable resources for the
development of therapeutics. Enzymatic and non-enzymatic proteins and peptides are the …

Evidence from both preclinical and clinical studies suggest the importance of zinc
homeostasis in seizures/epilepsy. Undoubtedly, zinc, via modulation of a variety of targets, is …

Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are
activated by pH drops and nonproton ligands. They are part of the degenerin/epithelial …

Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels
largely expressed in the nervous system of rodents and humans. At least six isoforms …

The rapid progress in mechanobiology has brought together many scientific and
engineering disciplines to work hand in hand toward better understanding of the role that …

Acid-sensing ion channels (ASICs) are proton-gated, voltage-independent sodium channels
widely expressed throughout the central and peripheral nervous systems. They are involved …