Modern viral kinetic modeling and its application to therapeutics is a field that attracted the
attention of the medical, pharmaceutical, and modeling communities during the early days of …

Viral infectious diseases are a global health concern, as is evident by recent outbreaks of
the middle east respiratory syndrome, Ebola virus disease, and re-emerging zika, dengue …

Recent studies reveal that cell-to-cell transmission via formation of virological synapses can
contribute significantly to virus spread, and hence, may play a more important role than virus …

We study the basic age-structured population model describing the HIV infection process,
which is defined by PDEs. The model allows the production rate of viral particles and the …

We present a model of HIV dynamics under antiretroviral therapy that combines drug
pharmacokinetics and intracellular delay. A two compartment pharmacokinetic model is …

Viral production from infected cells can occur continuously or in a burst that generally kills
the cell. For HIV infection, both modes of production have been suggested. Standard viral …

Various classes of antiretroviral drugs are used to treat HIV infection, and they target
different stages of the viral life cycle. Age-structured models can be employed to study the …

We consider the mathematical model for the viral dynamics of HIV-1 introduced in Rong et
al.(2007)[37]. One main feature of this model is that an eclipse stage for the infected cells is …

There are many biological steps between viral infection of CD4+ T cells and the production
of HIV-1 virions. Here we incorporate an eclipse phase, representing the stage in which …

Infectious pathogens compete and are subject to natural selection at multiple levels. For
example, viral strains compete for access to host resources within an infected host and, at …