Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

Ubiquitination, a pivotal posttranslational modification of proteins, plays a fundamental role
in regulating protein stability. The dysregulation of ubiquitinating and deubiquitinating …

The last 40 years have witnessed how p53 rose from a viral binding protein to a central
factor in both stress responses and tumor suppression. The exquisite regulation of p53 …

More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …

Iron overload triggers the ferroptosis in the heart following ischemia/reperfusion (I/R) and
transferrin receptor 1 (TfR1) charges the cellular iron uptake. Bioinformatics analysis shows …

Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes
to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and …

Tumors have evolved in various mechanisms to evade the immune system, hindering the
antitumor immune response and facilitating tumor progression. Immunotherapy has become …

Over the course of three decades of study, the deubiquitinase Herpesvirus associated
Ubiquitin-Specific Protease/Ubiquitin-Specific Protease 7 (HAUSP/USP7) has gradually …

The DNA damage response (DDR) is essential for maintaining the genomic integrity of the
cell, and its disruption is one of the hallmarks of cancer. Classically, defects in the DDR have …