Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary
heart disease (CHD). Globally, one baby is born with FH every minute. If diagnosed and …

Abstract Aims Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening
condition characterized by markedly elevated circulating levels of low-density lipoprotein …

Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and
experimental Klotho deficiency, but whether Klotho deficiency is responsible for the …

with the matrix and with the periodicity of negative charges on collagen. Crystals initially
form octacalcium phosphate [Ca8H2 (PO4) 6· 5H2O], which reorganizes and seeds epitaxial …

In the past decade, the prevalence, significance, and regulatory mechanisms of vascular
calcification have gained increasing recognition. Over a century ago, pathologists …

Background—Homozygous familial hypercholesterolemia is an inherited disorder caused by
mutations in both low-density lipoprotein receptor alleles, which results in extremely …

Homozygous familial hypercholesterolemia (HoFH) is an autosomal co-dominant disease
resulting from mutations in both copies of the low-density lipoprotein receptor (LDLR) gene …

Advanced glycation end products (AGEs) are a heterogenous group of molecules formed
during a non-enzymatic reaction between proteins and sugar residues. Recently, AGEs and …

Clinical trials have unequivocally shown that inhibition of proprotein convertase
subtilisin/kexin type 9 (PCSK9) efficaciously and safely prevents cardiovascular events by …

Although calcific aortic stenosis is a very common disease with major adverse
cardiovascular events and healthcare costs, there are no effective medical interventions to …