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PROTAC targeted protein degraders: the past is prologue
Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to
tackle disease-causing proteins that have historically been highly challenging to target with …
tackle disease-causing proteins that have historically been highly challenging to target with …
COVID-19: Discovery, diagnostics and drug development
Summary Coronavirus disease 2019 (COVID-19) started as an epidemic in Wuhan in 2019,
and has since become a pandemic. Groups from China identified and sequenced the virus …
and has since become a pandemic. Groups from China identified and sequenced the virus …
Employee engagement practices during COVID‐19 lockdown
In the present business situation during the COVID‐19 pandemic, employee engagement
has become one of the utmost prominent primacies for human resource managers and …
has become one of the utmost prominent primacies for human resource managers and …
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …
COVID-19: drug targets and potential treatments
Currently, humans are immersed in a pandemic caused by the emerging severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health …
respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health …
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
Progress and challenges in targeting the SARS-CoV-2 papain-like protease
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. The approval of vaccines
and small-molecule antivirals is vital in combating the pandemic. The viral polymerase …
and small-molecule antivirals is vital in combating the pandemic. The viral polymerase …
A global review on short peptides: frontiers and perspectives
Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …
entities via all domains of life and interfere with protein-protein interactions, which are …
Potent noncovalent inhibitors of the main protease of SARS-CoV-2 from molecular sculpting of the drug perampanel guided by free energy perturbation calculations
Starting from our previous finding of 14 known drugs as inhibitors of the main protease
(Mpro) of SARS-CoV-2, the virus responsible for COVID-19, we have redesigned the weak …
(Mpro) of SARS-CoV-2, the virus responsible for COVID-19, we have redesigned the weak …
Design of SARS-CoV-2 PLpro inhibitors for COVID-19 antiviral therapy leveraging binding cooperativity
Antiviral agents that complement vaccination are urgently needed to end the COVID-19
pandemic. The SARS-CoV-2 papain-like protease (PLpro), one of only two essential …
pandemic. The SARS-CoV-2 papain-like protease (PLpro), one of only two essential …