Infection initiates sepsis, but the clinical disease arises through the innate immune response
of the host. A rapidly evolving understanding of the biology of that response has not been …

Background We describe demographic features, treatments and clinical outcomes in the
International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID …

Lessons drawn from successes and failures with coronavirus disease 2019 (COVID-19) and
Ebola virus disease (EVD) should help sha** a robust health innovation system for …

Abstract The International Severe Acute Respiratory and Emerging Infection Consortium
(ISARIC) COVID-19 dataset is one of the largest international databases of prospectively …

Understanding the cause of sex disparities in COVID-19 outcomes is a major challenge. We
investigate sex hormone levels and their association with outcomes in COVID-19 patients …

The challenging work to find primary outcomes that reflect the diversity of disease and meet
the needs of patients, regulators, and public health officials is underway. It is uncertain …

Specialised pre-trained language models are becoming more frequent in Natural language
Processing (NLP) since they can potentially outperform models trained on generic texts …

Background The resources for critical care are limited in many settings, exacerbating the
significant morbidity and mortality associated with critical illness. Budget constraints can …

Background Compared to the abundance of clinical and genomic information available on
patients hospitalised with COVID-19 disease from high-income countries, there is a paucity …

Background During the COVID-19 pandemic, several methodologies were designed for
obtaining electronic health record (EHR)-derived datasets for research. These processes …