Joint conditions pose an important public health problem as they are a leading cause of
pain, functional limitation and physical disability. Oxidative stress is related to the …

Temporomandibular disorder (TMD) is an oral dentofacial disease that is related to multiple
factors such as disordered dental occlusion, emotional stress, and immune responses. In the …

Nitric oxide (NO) is an important part of the host defense mechanism; however, it displays
both pro-and anti-inflammatory properties depending on its location and concentration …

Biliverdin is one of the three by-products of heme oxygenase (HO) activity, the others being
ferrous iron and carbon monoxide. Under physiological conditions, once formed in the cell …

Neuropathic pain manifested with allodynia and hyperalgesia usually becomes a chronic
condition accompanied with mood disorders. Clinical therapies for neuropathic pain are still …

Objective To investigate the participation of canonical Wnt and NF-κB signaling pathways in
an experimental model of chronic arthritis induced by methylated bovine serum albumin …

Cadmium is toxic to the kidney through mechanisms involving oxidative stress and
inflammation. We studied reciprocal crosstalk among the oxidative stress, inflammation, and …

The prevalence of chronic widespread pain (CWP) in people with HIV is high, yet the
underlying mechanisms are elusive. Leukocytes synthesize the endogenous opioid, β …

Background: Hemin is clinically used in acute attacks of porphyria; however, recent
evidence has also highlighted its capability to stimulate the heme oxygenase enzyme, being …

Objective Moringa oleifera possesses multiple biological effects and the 4-[(4′-O-acetyl-α-L-
rhamnosyloxy) benzyl] isothiocyanate accounts for them. Based on the original …