The mechanistic target of rapamycin (mTOR): novel considerations as an antiviral treatment

K Maiese - Current Neurovascular Research, 2020 - ingentaconnect.com
Multiple viral pathogens can pose a significant health risk to individuals. As a recent
example, the β-coronavirus family virion, SARS-CoV-2, has quickly evolved as a pandemic …

Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1

K Maiese - Neural regeneration research, 2021 - journals.lww.com
The global increase in lifespan noted not only in developed nations, but also in large
develo** countries parallels an observed increase in a significant number of non …

Decoding clinical biomarker space of COVID-19: Exploring matrix factorization-based feature selection methods

F Saberi-Movahed, M Mohammadifard… - Computers in biology …, 2022 - Elsevier
One of the most critical challenges in managing complex diseases like COVID-19 is to
establish an intelligent triage system that can optimize the clinical decision-making at the …

Cognitive impairment and dementia: gaining insight through circadian clock gene pathways

K Maiese - Biomolecules, 2021 - mdpi.com
Neurodegenerative disorders affect fifteen percent of the world's population and pose a
significant financial burden to all nations. Cognitive impairment is the seventh leading cause …

Potential repositioning of anti-cancer EGFR inhibitors in Alzheimer's disease: current perspectives and challenging prospects

HM Mansour, HM Fawzy, AS El-Khatib, MM Khattab - Neuroscience, 2021 - Elsevier
Clinical trials of new drugs for Alzheimer's disease (AD) have ended with disappointing
results, with tremendous resources and time. Repositioning of existing anti-cancer …

[HTML][HTML] Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm

K Maiese - Frontiers in bioscience (Landmark edition), 2021 - ncbi.nlm.nih.gov
Methods and results: Novel work with biological clock genes that oversee circadian rhythm
may meet this critical need by focusing upon the pathways of the mechanistic target of …

Cognitive impairment in multiple sclerosis

K Maiese - Bioengineering, 2023 - mdpi.com
Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a
demyelinating disease in the nervous system with increased prevalence over the last five …

[HTML][HTML] Nicotinamide as a foundation for treating neurodegenerative disease and metabolic disorders

K Maiese - Current neurovascular research, 2021 - ncbi.nlm.nih.gov
Neurodegenerative disorders impact more than one billion individuals worldwide and are
intimately tied to metabolic disease that can affect another nine hundred individuals …

The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk

K Maiese - Frontiers in immunology, 2023 - frontiersin.org
Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …

[HTML][HTML] Innovative therapeutic strategies for cardiovascular disease

K Maiese - EXCLI journal, 2023 - ncbi.nlm.nih.gov
As a significant non-communicable disease, cardiovascular disease is the leading cause of
death for both men and women, comprises almost twenty percent of deaths in most racial …