Solid-state NMR spectroscopy is one of the most commonly used techniques to study the
atomic-resolution structure and dynamics of various chemical, biological, material, and …

Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …

Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Internuclear distances represent one of the main structural constraints in molecular structure
determination using solid-state NMR spectroscopy, complementing chemical shifts and …

Abstract Knowledge of the structure of amorphous solids can direct, for example, the
optimization of pharmaceutical formulations, but atomic-level structure determination in …

Amorphous solid dispersions (ASDs) are a formulation and development strategy that can
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …

Drug repositioning is defined as a process to identify a new application for drugs. This
approach is critical as it takes advantage of well-known pharmacokinetics …

The bioavailability of insoluble crystalline active pharmaceutical ingredients (APIs) can be
enhanced by formulation as amorphous solid dispersions (ASDs). One of the key factors of …

Pharmaceutical amorphous solid dispersions (ASDs) represent a widely used technology to
increase the bioavailability of active pharmaceutical ingredients (APIs). ASDs are based on …

Quantifying low-level components in solid-state analysis presents a significant challenge for
most thermal, diffractometric, vibrational, and spectroscopic techniques. In pharmaceutical …