Osteosarcoma is the most common primary malignant bone tumour in children and
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …

Simple Summary In this review, the authors propose a crosswise examination of cytarabine-
related issues ranging from the spectrum of clinical activity and severe toxicities, through …

The effective treatment of acute myeloid leukemia (AML) is very challenging. Due to the
immense heterogeneity of this disease, treating it using a “one size fits all” approach is …

Differentiation blockade is a hallmark of acute myeloid leukemia (AML). A strategy to
overcome such a blockade is a promising approach against the disease. The lack of …

The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is
an important anticancer strategy. The replication and repair of DNA are dependent upon the …

Nucleoside-based drugs, recognized as purine or pyrimidine analogs, have been potent
therapeutic agents since their introduction in 1950, deployed widely in the treatment of …

Background Treatment of newly diagnosed acute myeloid leukaemia (AML) is based on
combination chemotherapy with cytarabine (ara‐C) and anthracyclines. Five‐year overall …

Cytarabine (Ara-C) is the first-line drug for the treatment of acute myelogenous leukemia
(AML). However, resistance eventually develops, decreasing the efficacy of Ara-C in AML …

Cytotoxic chemotherapy remains a key modality in cancer treatment. These therapies,
successfully used for decades, continue to transform the lives of cancer patients daily. With …

Nucleotides are synthesized through two distinct pathways: de novo synthesis and
nucleoside salvage. Whereas the de novo pathway synthesizes nucleotides from amino …