The Warburg effect: a signature of mitochondrial overload
A long-standing question in cancer biology has been why oxygenated tumors ferment the
majority of glucose they consume to lactate rather than oxidizing it in their mitochondria, a …
majority of glucose they consume to lactate rather than oxidizing it in their mitochondria, a …
The Warburg effect: how does it benefit cancer cells?
Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term
maintenance. The common feature of this altered metabolism is the increased glucose …
maintenance. The common feature of this altered metabolism is the increased glucose …
Cancer metabolism: a therapeutic perspective
UE Martinez-Outschoorn, M Peiris-Pagés… - Nature reviews Clinical …, 2017 - nature.com
Awareness that the metabolic phenotype of cells within tumours is heterogeneous—and
distinct from that of their normal counterparts—is growing. In general, tumour cells …
distinct from that of their normal counterparts—is growing. In general, tumour cells …
Fast automated reconstruction of genome-scale metabolic models for microbial species and communities
Genome-scale metabolic models are instrumental in uncovering operating principles of
cellular metabolism, for model-guided re-engineering, and unraveling cross-feeding in …
cellular metabolism, for model-guided re-engineering, and unraveling cross-feeding in …
Improving the phenotype predictions of a yeast genome‐scale metabolic model by incorporating enzymatic constraints
Genome‐scale metabolic models (GEM s) are widely used to calculate metabolic
phenotypes. They rely on defining a set of constraints, the most common of which is that the …
phenotypes. They rely on defining a set of constraints, the most common of which is that the …
Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells
AM Hosios, VC Hecht, LV Danai, MO Johnson… - Developmental cell, 2016 - cell.com
Cells must duplicate their mass in order to proliferate. Glucose and glutamine are the major
nutrients consumed by proliferating mammalian cells, but the extent to which these and …
nutrients consumed by proliferating mammalian cells, but the extent to which these and …
Single-cell RNA sequencing maps endothelial metabolic plasticity in pathological angiogenesis
Endothelial cell (EC) metabolism is an emerging target for anti-angiogenic therapy in tumor
angiogenesis and choroidal neovascularization (CNV), but little is known about individual …
angiogenesis and choroidal neovascularization (CNV), but little is known about individual …
[HTML][HTML] Biomarkers of nutrition for development—folate review
Abstract The Biomarkers of Nutrition for Development (BOND) project is designed to provide
evidence-based advice to anyone with an interest in the role of nutrition in health …
evidence-based advice to anyone with an interest in the role of nutrition in health …
Targeting cancer metabolism: a therapeutic window opens
MG Vander Heiden - Nature reviews Drug discovery, 2011 - nature.com
Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical
evidence has linked cell metabolism with cancer outcomes. Together, these observations …
evidence has linked cell metabolism with cancer outcomes. Together, these observations …
Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia
Mammalian cells can generate ATP via glycolysis or mitochondrial respiration. Oncogene
activation and hypoxia promote glycolysis and lactate secretion. The significance of these …
activation and hypoxia promote glycolysis and lactate secretion. The significance of these …