Chitosan: An overview of biological activities, derivatives, properties, and current advancements in biomedical applications.

GI Edo, E Yousif, MH Al-Mashhadani - Carbohydrate Research, 2024 - Elsevier
The second and most often utilized natural polymer is chitosan (CS), a naturally existing
amino polysaccharide that is produced by deacetylating chitin. Numerous applications have …

[HTML][HTML] Chitosan in oral drug delivery formulations: A review

T Sangnim, D Dheer, N Jangra, K Huanbutta, V Puri… - Pharmaceutics, 2023 - mdpi.com
Nanoformulations have become increasingly useful as drug delivery technologies in recent
decades. As therapeutics, oral administration is the most common delivery method, although …

Enhancing therapeutic efficacy: sustained delivery of 5-fluorouracil (5-FU) via thiolated chitosan nanoparticles targeting CD44 in triple-negative breast cancer

S Anjum, F Naseer, T Ahmad, F Jahan, H Qadir… - Scientific reports, 2024 - nature.com
Our current study reports the successful synthesis of thiolated chitosan-based nanoparticles
for targeted drug delivery of 5-Fluorouracil. This process was achieved through the ionic …

Nanodrugs based on co-delivery strategies to combat cisplatin resistance

Q Wang, H Li, T Wu, B Yu, H Cong, Y Shen - Journal of Controlled Release, 2024 - Elsevier
Cisplatin (CDDP), as a broad-spectrum anticancer drug, is able to bind to DNA and inhibit
cell division. Despite the widespread use of cisplatin since its discovery, cisplatin resistance …

Recent advances on chitosan/hyaluronic acid-based stimuli-responsive hydrogels and composites for cancer treatment: A comprehensive review

F Alsaikhan, B Farhood - International Journal of Biological …, 2024 - Elsevier
Cancer, as leading cause of death, has a high rate of mortality worldwide. Although there is
a wide variety of conventional approaches for the treatment of cancer (such as surgery and …

CD44 targeted delivery of oncolytic Newcastle disease virus encapsulated in thiolated chitosan for sustained release in cervical cancer: a targeted immunotherapy …

K Kousar, F Naseer, MS Abduh, S Anjum… - Frontiers in …, 2023 - frontiersin.org
Introduction Cervical cancer accounts for one of most common cancers among women of
reproductive age. Oncolytic virotherapy has emerged as a promising immunotherapy …

A carrier-free metal-phenolic network with enhanced ferroptosis-immunotherapy for overcoming tumor resistance and metastasis

N Zhang, Z Wang, G Li, M Zhang, Q Liu, C Cai… - Chemical Engineering …, 2024 - Elsevier
The development of multidrug resistance (MDR) is the primary contributor to the failure of
cancer treatment, ultimately leading to tumor recurrence and metastasis. Ferroptosis, an iron …

Chitosan nanoparticles for targeted cancer therapy: A review of stimuli-responsive, passive, and active targeting strategies

JRMH Al-Shadidi, S Al-Shammari… - International Journal …, 2024 - Taylor & Francis
Despite all major advancements in drug discovery and development in the pharmaceutical
industry, cancer is still one of the most arduous challenges for the scientific community. The …

[HTML][HTML] Advances in the delivery of anticancer drugs by nanoparticles and chitosan-based nanoparticles

J Prieložná, V Mikušová, P Mikuš - International Journal of Pharmaceutics …, 2024 - Elsevier
Cancer is the leading cause of death globally, and conventional treatments have limited
efficacy with severe side effects. The use of nanotechnology has the potential to reduce the …

Biopolymer-based nanomedicine for cancer therapy: opportunities and challenges

X Wu, Y **n, H Zhang, L Quan, Q Ao - International Journal of …, 2024 - Taylor & Francis
Cancer, as the foremost challenge among human diseases, has plagued medical
professionals for many years. While there have been numerous treatment approaches in …