Genetics of human brain development
Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …
the mechanisms of which remain largely elusive. Recently, integration of technological …
Human neuronal maturation comes of age: cellular mechanisms and species differences
The delayed and prolonged postmitotic maturation of human neurons, compared with
neurons from other species, may contribute to human-specific cognitive abilities and …
neurons from other species, may contribute to human-specific cognitive abilities and …
Evolutionary constraint and innovation across hundreds of placental mammals
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
[HTML][HTML] Protracted neuronal recruitment in the temporal lobes of young children
The temporal lobe of the human brain contains the entorhinal cortex (EC). This region of the
brain is a highly interconnected integrative hub for sensory and spatial information; it also …
brain is a highly interconnected integrative hub for sensory and spatial information; it also …
Massively parallel characterization of regulatory elements in the develo** human cortex
Nucleotide changes in gene regulatory elements are important determinants of neuronal
development and diseases. Using massively parallel reporter assays in primary human cells …
development and diseases. Using massively parallel reporter assays in primary human cells …
Rare variation in non-coding regions with evolutionary signatures contributes to autism spectrum disorder risk
Little is known about the role of non-coding regions in the etiology of autism spectrum
disorder (ASD). We examined three classes of non-coding regions: human accelerated …
disorder (ASD). We examined three classes of non-coding regions: human accelerated …
Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment
Human accelerated regions (HARs) have been implicated in human brain evolution.
However, insight into the genes and pathways they control is lacking, hindering the …
However, insight into the genes and pathways they control is lacking, hindering the …
[HTML][HTML] Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the develo** human cortex
Nucleotide changes in gene regulatory elements are important determinants of neuronal
development and disease. Using massively parallel reporter assays in primary human cells …
development and disease. Using massively parallel reporter assays in primary human cells …
Detection and analysis of complex structural variation in human genomes across populations and in brains of donors with psychiatric disorders
Complex structural variations (cxSVs) are often overlooked in genome analyses due to
detection challenges. We developed ARC-SV, a probabilistic and machine-learning-based …
detection challenges. We developed ARC-SV, a probabilistic and machine-learning-based …
[HTML][HTML] If you please, draw me a neuron—linking evolutionary tinkering with human neuron evolution
Animal speciation often involves novel behavioral features that rely on nervous system
evolution. Human-specific brain features have been proposed to underlie specialized …
evolution. Human-specific brain features have been proposed to underlie specialized …