Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand

AO Elzoghby, MA Abdelmoneem, IA Hassanin… - Biomaterials, 2020 - Elsevier
Recent progress in protein-based nanomedicine, inspired by the success of Abraxane®
albumin-paclitaxel nanoparticles, have resulted in novel therapeutics used for treatment of …

Metabolism and pharmacological activities of the natural health-benefiting compound diosmin

Y Zheng, R Zhang, W Shi, L Li, H Liu, Z Chen, L Wu - Food & function, 2020 - pubs.rsc.org
Diosmin is a famous natural flavonoid for treating chronic venous insufficiency and varicose
veins. Recently, extensive study has indicated that diosmin possesses diverse …

A novel 'smart'PNIPAM-based copolymer for breast cancer targeted therapy: Synthesis, and characterization of dual pH/temperature-responsive lactoferrin-targeted …

ORM Metawea, MA Abdelmoneem, NS Haiba… - Colloids and Surfaces B …, 2021 - Elsevier
Despite the active research towards introducing novel anticancer agents, the long-term
sequelae and side effects of chemotherapy remain the major obstacle to achieving clinical …

Recent advances in herbal combination nanomedicine for cancer: delivery technology and therapeutic outcomes

DM Anwar, M El-Sayed, A Reda, JY Fang… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: The use of herbal compounds in cancer therapy has great potential to promote
the efficacy of current cancer therapeutic strategies. Herbal compounds were successfully …

Lactoferrin coated or conjugated nanomaterials as an active targeting approach in nanomedicine

MM Agwa, S Sabra - International Journal of Biological Macromolecules, 2021 - Elsevier
A successful drug delivery to a specific site relies on two essential factors including; efficient
entrapment of the drug within the carrier and successful delivery of drug-loaded nanocarrier …

Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: A repurposing approach

M Kharouba, A El-Kamel, R Mehanna, E Thabet… - Drug Delivery, 2022 - Taylor & Francis
Albeit its established efficacy as an anti-hyperlipidemic agent, pitavastatin (PIT) has been
shown to have other various therapeutic effects. One of these effects is the anti-cancer …

Dual-targeted lactoferrin shell-oily core nanocapsules for synergistic targeted/herbal therapy of hepatocellular carcinoma

MA Abdelmoneem, MA Elnaggar… - … applied materials & …, 2019 - ACS Publications
Herein, both strategies of synergistic drug combination together with dual active tumor
targeting were combined for effective therapy of hepatocellular carcinoma (HCC). Therefore …

Lactoferrin-dual drug nanoconjugate: Synergistic anti-tumor efficacy of docetaxel and the NF-κB inhibitor celastrol

MA Abdelmoneem, MM Abd Elwakil, SN Khattab… - Materials Science and …, 2021 - Elsevier
Despite the progress in cancer nanotherapeutics, some obstacles still impede the success of
nanocarriers and hinder their clinical translation. Low drug loading, premature drug release …

Targeting cancer with lactoferrin nanoparticles: recent advances

AK Kondapi - Nanomedicine, 2020 - Taylor & Francis
Lactoferrin, an iron storage protein, is known for its microbicidal activity and its ability to
modulate the immune system, mediated through specific interactions with receptors on cell …

Development of encapsulation strategies and composite edible films to maintain lactoferrin bioactivity: A review

I Abad, C Conesa, L Sánchez - Materials, 2021 - mdpi.com
Lactoferrin (LF) is a whey protein with various and valuable biological activities. For this
reason, LF has been used as a supplement in formula milk and functional products …