Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …

The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Although the shapes of organisms are encoded in their genome, the developmental
processes that lead to the final form of vertebrates involve a constant feedback between …

During cell migration, the forces generated in the actin cytoskeleton are transmitted across
transmembrane receptors to the extracellular matrix or other cells through a series of …

Recent evidence has shown that, in addition to rigidity, the viscous response of the
extracellular matrix (ECM) significantly affects the behavior and function of cells. However …

The role of tumor microenvironment in cancer progression is gaining significant attention. It
is realized that cancer cells and the corresponding stroma co-evolve with time. Cancer cells …

In biomaterials science, it is nowadays well accepted that improving the biointegration of
dental and orthopedic implants with surrounding tissues is a major goal. However, implant …

The recent convergence between physics and biology has led many physicists to enter the
fields of cell and developmental biology. One of the most exciting areas of interest has been …

Directional cell migration normally relies on a variety of external signals, such as chemical,
mechanical, or electrical, which instruct cells in which direction to move. Many of the major …