Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …

Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide-binding (G)
proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and …

Hundreds of E3 ligases play a critical role in recognizing specific substrates for modification
by ubiquitin (Ub). Separating genuine targets of E3s from E3-interactors remains a …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Since their discovery, extracellular vesicles (EVs) have changed our view on how organisms
interact with their extracellular world. EVs are able to traffic a diverse array of molecules …

The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …

Small GTP-binding proteins regulate diverse processes in eukaryotic cells such as signal
transduction, cell proliferation, cytoskeletal organization, and intracellular membrane …

Small G proteins play a central role in the organization of the secretory and endocytic
pathways. The majority of such small G proteins are members of the Rab family, which are …

Transport of membranes and proteins in eukaryotic cells is mediated by vesicular carriers.
Here we review the biogenesis and functions of COPI vesicles, carriers that operate in the …

EEA1, a 162-kDa autoantigen associated with subacute cutaneous systemic lupus
erythematosus, is a coiled-coil protein localized to early endosomes and cytosol. At its C …