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Understanding the genetic basis of variation in meiotic recombination: past, present, and future
Meiotic recombination is a fundamental feature of sexually reproducing species. It is often
required for proper chromosome segregation and plays important role in adaptation and the …
required for proper chromosome segregation and plays important role in adaptation and the …
Meiotic recombination: the essence of heredity
The study of homologous recombination has its historical roots in meiosis. In this context,
recombination occurs as a programmed event that culminates in the formation of crossovers …
recombination occurs as a programmed event that culminates in the formation of crossovers …
Multi-platform discovery of haplotype-resolved structural variation in human genomes
The incomplete identification of structural variants (SVs) from whole-genome sequencing
data limits studies of human genetic diversity and disease association. Here, we apply a …
data limits studies of human genetic diversity and disease association. Here, we apply a …
Control of meiotic crossovers: from double-strand break formation to designation
Meiosis, the mechanism of creating haploid gametes, is a complex cellular process
observed across sexually reproducing organisms. Fundamental to meiosis is the process of …
observed across sexually reproducing organisms. Fundamental to meiosis is the process of …
Initial sequencing and analysis of the human genome
US DOE Joint Genome Institute: Hawkins Trevor 4 … - nature, 2001 - nature.com
The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …
physiology, medicine and evolution. Here we report the results of an international …
The human genome browser at UCSC
As vertebrate genome sequences near completion and research refocuses to their analysis,
the issue of effective genome annotation display becomes critical. A mature web tool for …
the issue of effective genome annotation display becomes critical. A mature web tool for …
The sequence of the human genome
A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …
Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies
We describe extensions to the method of Pritchard et al. for inferring population structure
from multilocus genotype data. Most importantly, we develop methods that allow for linkage …
from multilocus genotype data. Most importantly, we develop methods that allow for linkage …
Gender differences in cancer susceptibility: an inadequately addressed issue
The gender difference in cancer susceptibility is one of the most consistent findings in
cancer epidemiology. Hematologic malignancies are generally more common in males and …
cancer epidemiology. Hematologic malignancies are generally more common in males and …
[HTML][HTML] Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
Background The molecular cause of inflammatory bowel disease is largely unknown.
Methods We performed genetic-linkage analysis and candidate-gene sequencing on …
Methods We performed genetic-linkage analysis and candidate-gene sequencing on …