Targeting fibrosis: Mechanisms and clinical trials
M Zhao, L Wang, M Wang, S Zhou, Y Lu… - Signal transduction and …, 2022 - nature.com
Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …
dysregulated wound and connective tissue repair response. Multiple organs can develop …
Impact of the Human Cell Atlas on medicine
Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …
therapies. By identifying the specific cell types, states, programs and contexts where disease …
An integrated cell atlas of the lung in health and disease
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions …
typically capture only a limited number of donors and disagree on cell type definitions …
A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …
Dictionary learning for integrative, multimodal and scalable single-cell analysis
Map** single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …
powerful alternative to unsupervised analysis. However, most reference datasets are …
Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis
Fibroblasts are present throughout the body and function to maintain tissue homeostasis.
Recent studies have identified diverse fibroblast subsets in healthy and injured tissues,, but …
Recent studies have identified diverse fibroblast subsets in healthy and injured tissues,, but …
Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation
Macrophages are central orchestrators of the tissue response to injury, with distinct
macrophage activation states playing key roles in fibrosis progression and resolution …
macrophage activation states playing key roles in fibrosis progression and resolution …
Interstitial lung diseases
Over 200 interstitial lung diseases, from ultra rare to relatively common, are recognised.
Most interstitial lung diseases are characterised by inflammation or fibrosis within the …
Most interstitial lung diseases are characterised by inflammation or fibrosis within the …