Imaging biomarkers of vulnerable carotid plaques for stroke risk prediction and their potential clinical implications

L Saba, T Saam, HR Jäger, C Yuan… - The Lancet …, 2019 - thelancet.com
Stroke represents a massive public health problem. Carotid atherosclerosis plays a
fundamental part in the occurence of ischaemic stroke. European and US guidelines for …

Inflammation and stroke risk: a new target for prevention

PJ Kelly, R Lemmens, G Tsivgoulis - Stroke, 2021 - Am Heart Assoc
New therapeutic approaches are required for secondary prevention of residual vascular risk
after stroke. Diverse sources of evidence support a causal role for inflammation in the …

Review and update of the concept of embolic stroke of undetermined source

HC Diener, JD Easton, RG Hart, S Kasner… - Nature Reviews …, 2022 - nature.com
Ischaemic strokes have traditionally been classified according to the TOAST criteria, in
which strokes with unclear aetiology are classified as cryptogenic strokes. However, the …

Vascular inflammation in subclinical atherosclerosis detected by hybrid PET/MRI

L Fernandez-Friera, V Fuster, B Lopez-Melgar… - Journal of the American …, 2019 - jacc.org
Background: Atherosclerosis is a chronic inflammatory disease, but data on arterial
inflammation at early stages is limited. Objectives: The purpose of this study was to …

Efficacy and safety of rivaroxaban versus aspirin in embolic stroke of undetermined source and carotid atherosclerosis

G Ntaios, B Swaminathan, SD Berkowitz, RJ Gagliardi… - Stroke, 2019 - Am Heart Assoc
Background and Purpose—The sources of emboli in patients with embolic stroke of
undetermined source (ESUS) are multiple and may not respond uniformly to …

Carotid plaque with high-risk features in embolic stroke of undetermined source: systematic review and meta-analysis

J Kamtchum-Tatuene, A Wilman, M Saqqur, A Shuaib… - Stroke, 2020 - Am Heart Assoc
Background and Purpose—An ipsilateral mild carotid stenosis, defined as plaque with< 50%
luminal narrowing, is identified in nearly 40% of patients with embolic stroke of …

Characteristics of recurrent ischemic stroke after embolic stroke of undetermined source: secondary analysis of a randomized clinical trial

R Veltkamp, LA Pearce, E Korompoki… - JAMA …, 2020 - jamanetwork.com
Importance The concept of embolic stroke of undetermined source (ESUS) unifies a
subgroup of cryptogenic strokes based on neuroimaging, a defined minimum set of …

Supracardiac atherosclerosis in embolic stroke of undetermined source: the underestimated source

G Ntaios, M Wintermark, P Michel - European heart journal, 2021 - academic.oup.com
The term 'embolic stroke of undetermined source'(ESUS) is used to describe patients with a
non-lacunar ischaemic stroke without any identified embolic source from the heart or the …

Vessel wall–imaging biomarkers of carotid plaque vulnerability in stroke prevention trials: a viewpoint from the Carotid Imaging Consensus Group

L Saba, AR Moody, T Saam, ME Kooi… - Cardiovascular …, 2020 - jacc.org
Acute ischemic stroke is a major cause of morbidity and mortality worldwide and its
incidence is about 200 per 100,000 population per year (1). Approximately 20% of patients …

Identification of patients with embolic stroke of undetermined source and low risk of new incident atrial fibrillation: the AF-ESUS score

G Ntaios, K Perlepe, D Lambrou… - … Journal of Stroke, 2021 - journals.sagepub.com
Background and aims Only a minority of patients with Embolic Stroke of Undetermined
Source (ESUS) receive prolonged cardiac monitoring despite current recommendations …