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Mechanisms of MHC class I–restricted antigen processing
▪ Abstract Classical class I molecules assemble in the endoplasmic reticulum (ER) with
peptides mostly generated from cytosolic proteins by the proteasome. The activity of the …
peptides mostly generated from cytosolic proteins by the proteasome. The activity of the …
Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E
Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed,
nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in …
nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in …
A soluble single-chain T-cell receptor IL-2 fusion protein retains MHC-restricted peptide specificity and IL-2 bioactivity
Antibody-based targeted immunotherapy has shown promise as an approach to treat
cancer. However, many known tumor-associated antigens are not expressed as integral …
cancer. However, many known tumor-associated antigens are not expressed as integral …
NetCTLpan: pan-specific MHC class I pathway epitope predictions
Reliable predictions of immunogenic peptides are essential in rational vaccine design and
can minimize the experimental effort needed to identify epitopes. In this work, we describe a …
can minimize the experimental effort needed to identify epitopes. In this work, we describe a …
Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD
Skeletal muscle differentiation entails the coordination of muscle-specific gene expression
and terminal withdrawal from the cell cycle. This cell cycle arrest in the G0 phase requires …
and terminal withdrawal from the cell cycle. This cell cycle arrest in the G0 phase requires …
Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP
Assembly of MHC class I–β 2 microglobulin (β 2 m) dimers in the endoplasmic reticulum
involves two chaperones. Calnexin has previously been shown to interact with free class I …
involves two chaperones. Calnexin has previously been shown to interact with free class I …
Enhanced and prolonged cross‐presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles
CD8+ T‐cell responses are critical in the immunological control of tumours and infectious
diseases. To prime CD8+ T cells against these cell‐associated antigens, exogenous …
diseases. To prime CD8+ T cells against these cell‐associated antigens, exogenous …
Generation and TAP-mediated transport of peptides for major histocompatibility complex class I molecules
Publisher Summary This chapter reviews the generation and TAP-mediated transport of
peptides for major histocompatibility complex class I molecules. The translocation of …
peptides for major histocompatibility complex class I molecules. The translocation of …
Mesothelin-specific CD8+ T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients
AM Thomas, LM Santarsiero, ER Lutz… - Journal of Experimental …, 2004 - rupress.org
Tumor-specific CD8 T cells can potentially be activated by two distinct mechanisms of major
histocompatibility complex class I–restricted antigen presentation as follows: direct …
histocompatibility complex class I–restricted antigen presentation as follows: direct …
Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine
KY Tsang, S Zaremba, CA Nieroda… - JNCI: Journal of the …, 1995 - academic.oup.com
Background: The human carcinoembryonic antigen (CEA), which is expressed in several
cancer types, is a potential target for specific immunotherapy using recombinant vaccines …
cancer types, is a potential target for specific immunotherapy using recombinant vaccines …