Best practices for single-cell analysis across modalities
Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …
The molecular mechanisms that underlie the immune biology of anti-drug antibody formation following treatment with monoclonal antibodies
A Vaisman-Mentesh, M Gutierrez-Gonzalez… - Frontiers in …, 2020 - frontiersin.org
Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …
however, the repeated administration of mAbs can be highly immunogenic. Drug …
COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning
To ultimately combat the emerging COVID-19 pandemic, it is desired to develop an effective
and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 …
and safe vaccine against this highly contagious disease caused by the SARS-CoV-2 …
[HTML][HTML] Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses
JT Ladner, SN Henson, AS Boyle… - Cell Reports …, 2021 - cell.com
The SARS-CoV-2 proteome shares regions of conservation with endemic human
coronaviruses (CoVs), but it remains unknown to what extent these may be cross …
coronaviruses (CoVs), but it remains unknown to what extent these may be cross …
IEDB-AR: immune epitope database—analysis resource in 2019
Abstract The Immune Epitope Database Analysis Resource (IEDB-AR, http://tools. iedb. org/)
is a companion website to the IEDB that provides computational tools focused on the …
is a companion website to the IEDB that provides computational tools focused on the …
Designing a novel multi-epitope vaccine to evoke a robust immune response against pathogenic multidrug-resistant Enterococcus faecium bacterium
Enterococcus faecium is an emerging ESKAPE bacterium that is capable of causing severe
public health complications in humans. There are currently no licensed treatments or …
public health complications in humans. There are currently no licensed treatments or …
Multi-modal generative modeling for joint analysis of single-cell T cell receptor and gene expression data
Recent advances in single-cell immune profiling have enabled the simultaneous
measurement of transcriptome and T cell receptor (TCR) sequences, offering great potential …
measurement of transcriptome and T cell receptor (TCR) sequences, offering great potential …
Exploring the out of sight antigens of SARS-CoV-2 to design a candidate multi-epitope vaccine by utilizing immunoinformatics approaches
SARS-CoV-2 causes a severe respiratory disease called COVID-19. Currently, global health
is facing its devastating outbreak. However, there is no vaccine available against this virus …
is facing its devastating outbreak. However, there is no vaccine available against this virus …
GIANA allows computationally-efficient TCR clustering and multi-disease repertoire classification by isometric transformation
Similarity in T-cell receptor (TCR) sequences implies shared antigen specificity between
receptors, and could be used to discover novel therapeutic targets. However, existing …
receptors, and could be used to discover novel therapeutic targets. However, existing …
Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity
M Bassani-Sternberg, C Chong… - PLoS computational …, 2017 - journals.plos.org
The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a
central role in our ability to understand and predict (neo-) antigen presentation in infectious …
central role in our ability to understand and predict (neo-) antigen presentation in infectious …